Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23113991 | 0.84 | HTT (0.38) | HTTLMNAPOLBMEN1KMT2A | |
| SCHEMBL23113901 | 0.84 | HTT (0.41) | HTTLMNAPOLBPPARGMEN1 | |
| SCHEMBL23114100 | 0.81 | HTT (0.41) | HTTLMNAPOLBMEN1KMT2A | |
| SCHEMBL30541841 | 0.81 | AAK1 (0.39) | LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26050870 | 0.81 | AAK1 (0.39) | LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17782059 | 0.75 | HTT (0.44) | HTTLMNAPOLBPPARGMEN1 | |
| SCHEMBL1343874 | 0.75 | GPR139 (0.48) | HTTLMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL1343907 | 0.75 | MEN1 (0.46) | HTTLMNAPOLBMEN1KMT2A | |
| SCHEMBL12533352 | 0.75 | P2RX7 (0.31) | — | |
| SCHEMBL23114131 | 0.73 | KLKB1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3793994-A1 | INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE | Biogen MA Inc. (US) | 2021-03-24 | — | — | EP | disclosed |