Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.34 |
| ▸ | OGA | O60502 | 4/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23425821 | 1.00 | MCHR1 (0.34) | MCHR1KDM4EKAT2BOGAHSD11B1 | |
| SCHEMBL23089230 | 0.87 | ALOX5AP (0.35) | MCHR1KDM4EKAT2BDPP4KCNH2 | |
| SCHEMBL29736774 | 0.87 | ALOX5AP (0.35) | MCHR1KDM4EKAT2BDPP4KCNH2 | |
| SCHEMBL29814808 | 0.87 | ALOX5AP (0.35) | MCHR1KDM4EKAT2BDPP4KCNH2 | |
| SCHEMBL24859594 | 0.85 | KMT2A (0.39) | MCHR1KDM4EKAT2BALDH1A1KCNH2 | |
| SCHEMBL23106973 | 0.85 | KMT2A (0.39) | MCHR1KDM4EKAT2BALDH1A1KCNH2 | |
| SCHEMBL23107567 | 0.85 | KMT2A (0.39) | MCHR1KDM4EKAT2BALDH1A1KCNH2 | |
| SCHEMBL25147048 | 0.85 | MCHR1 (0.33) | MCHR1KDM4EKAT2BOGAALDH1A1 | |
| SCHEMBL23108847 | 0.84 | MCHR1 (0.34) | MCHR1KDM4EKAT2BOGAALDH1A1 | |
| SCHEMBL23102948 | 0.84 | MCHR1 (0.34) | MCHR1KDM4EKAT2BOGAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | SCHRÖDINGER, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20210078996-A1 | HPK1 ANTAGONISTS AND USES THEREOF | CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED (GB) | 2021-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025898-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | MCHR1 1383/4885KDM4E 3143/4885KAT2B 3660/4885 |
| US-20210078996-A1 | HPK1 ANTAGONISTS AND USES THEREOF | PDXK, HIPK1, PCK1 | MCHR1 1383/4885KDM4E 3143/4885KAT2B 3660/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.