SCHEMBL23116138

SCHEMBL23116138

C[C@@H](Oc1ccc(Br)cn1)C(F)(F)F

nearest known ligand 0.36

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
THRB P10828 1/20 0.36
LIPE Q05469 2/20 0.36
ALDH1A1 P00352 3/20 0.33
KDM4E B2RXH2 2/20 0.33
DGAT1 O75907 1/20 0.33
GABRA5 P31644 3/20 0.33
GBA1 P04062 1/20 0.33
CYP11B1 P15538 1/20 0.32
GPR88 Q9GZN0 2/20 0.32
ACACB O00763 1/20 0.31
LRRK2 Q5S007 1/20 0.31
GABRA1 P14867 2/20 0.31
GABRG2 P18507 2/20 0.31
GABRB3 P28472 2/20 0.31
GABRA3 P34903 2/20 0.31
GABRA2 P47869 2/20 0.31
CNR2 P34972 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20203926 1.00 THRB (0.36) THRBLIPEALDH1A1KDM4EDGAT1
SCHEMBL22711899 1.00 THRB (0.36) THRBLIPEALDH1A1KDM4EDGAT1
SCHEMBL23414302 0.88 THRB (0.35) THRBALDH1A1KDM4EDGAT1GABRA5
SCHEMBL23414198 0.83 THRB (0.35) THRBALDH1A1KDM4EGABRA5GBA1
SCHEMBL23600940 0.81 CCR1 (0.38) LIPEALDH1A1KDM4EGABRA5CYP11B1
SCHEMBL29499578 0.81 LIPE (0.36) LIPEALDH1A1KDM4EGABRA5CYP11B1
SCHEMBL23414081 0.80 GBA1 (0.38) THRBALDH1A1KDM4EDGAT1GABRA5
SCHEMBL735634 0.80 ALDH1A1 (0.49) ALDH1A1KDM4EGABRA5GBA1ACACB
SCHEMBL11289 0.79 KDM4E (0.44) LIPEALDH1A1KDM4ECYP11B1GPR88
SCHEMBL10363 0.79 KDM4E (0.44) LIPEALDH1A1KDM4ECYP11B1GPR88

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376475-A1 ION CHANNEL MODULATORS PRAXIS PREC MEDICINES INC (US) 2025-12-11 US disclosed
US-20250145629-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2025-05-08 US disclosed
EP-4487916-A2 ION CHANNEL MODULATORS Praxis Precision Medicines, Inc. (US) 2025-01-08 EP disclosed
US-12145939-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-11-19 US disclosed
US-20240132501-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. (US) 2024-04-25 US disclosed
CN-117756800-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2024-03-26 CN disclosed
US-20240043433-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2024-02-08 US disclosed
US-11866439-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-01-09 US disclosed
US-11767325-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2023-09-26 US disclosed
US-20230286984-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2023-09-14 US disclosed
CN-114980899-A Ion channel modulators 普拉西斯精密医药公司 2022-08-30 CN disclosed
US-20220220118-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2022-07-14 US disclosed
US-20220024930-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2022-01-27 US disclosed
US-20210171530-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-06-10 US disclosed
WO-2021108513-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. (US) 2021-06-03 WO disclosed
WO-2021108513-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. (US) 2021-06-03 WO disclosed
US-20210163488-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-06-03 US disclosed
US-11014931-B2 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator PRAXIS PRECISION MEDICINES, INC. (US) 2021-05-25 US disclosed
US-20210087197-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-03-25 US disclosed
CN-112423760-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2021-02-26 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (14 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240132501-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-20220220118-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-20210087197-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-12145939-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators SCN1A, SCN2A, SCN5A THRB 1769/4885LIPE 4662/4885ALDH1A1 1576/4885
US-20230286984-A1 ION CHANNEL MODULATORS SCN1A, SCN1B, SCN2A THRB 2758/4885LIPE 4519/4885ALDH1A1 1375/4885
US-11866439-B2 Ion channel modulators SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-20210163488-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-20220024930-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-20250145629-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-20240043433-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-11767325-B2 Substituted [1,2,4]triazolo[4,3-a]pyrazines as ion channel modulators SCN1A, SCN2A, SCN5A THRB 1636/4885LIPE 4668/4885ALDH1A1 1641/4885
US-20210171530-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885
US-11014931-B2 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator SCN3A, SCN1A, SCN5A THRB 2751/4885LIPE 4683/4885ALDH1A1 2271/4885
US-20250376475-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A THRB 2584/4885LIPE 4223/4885ALDH1A1 1953/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.