Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | MGLL | Q99685 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | EED | O75530 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29839301 | 0.92 | MGLL (0.41) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL22729560 | 0.92 | MGLL (0.41) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL23116378 | 0.89 | ALDH1A1 (0.36) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL29839291 | 0.88 | DRD3 (0.35) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL22729584 | 0.88 | DRD3 (0.35) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL22729439 | 0.87 | KDM4E (0.35) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL22729600 | 0.87 | ALDH1A1 (0.39) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL29839324 | 0.87 | ALDH1A1 (0.39) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL29839348 | 0.87 | KDM4E (0.35) | ALDH1A1MAPTHSD17B10HPGDKDM4E | |
| SCHEMBL22729581 | 0.87 | HCRTR1 (0.36) | ALDH1A1MAPTHSD17B10HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11459325-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-10-04 | — | — | US | disclosed |
| US-20210087186-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-03-25 | — | — | US | disclosed |
| US-20210087186-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210087186-A1 | HETEROCYCLIC COMPOUND | GBA1, GBA2, GALC | ALDH1A1 2626/4885MAPT 356/4885HSD17B10 1790/4885 |
| US-11459325-B2 | Heterocyclic compound | GBA1, GBA2, GALC | ALDH1A1 2660/4885MAPT 364/4885HSD17B10 1691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.