Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | MLYCD | O95822 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5090319 | 0.91 | MEN1 (0.50) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6295798 | 0.88 | MLYCD (0.48) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14799729 | 0.86 | MLYCD (0.41) | SMN1; SMN2MEN1KMT2AF2MLYCD | |
| SCHEMBL27572033 | 0.83 | TP53 (0.54) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL1624311 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL25736671 | 0.82 | MEN1 (0.50) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4312600 | 0.82 | MEN1 (0.50) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9407535 | 0.82 | MEN1 (0.50) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9524232 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5849328 | 0.81 | MLYCD (0.41) | SMN1; SMN2MEN1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021053158-A1 | NOVEL HISTONE METHYLTRANSFERASE INHIBITORS | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2021-03-25 | — | — | WO | disclosed |