Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.80 |
| ▸ | MAPT | P10636 | 9/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.80 |
| ▸ | HTT | P42858 | 8/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.80 |
| ▸ | LMNA | P02545 | 7/20 | 0.80 |
| ▸ | MPI | P34949 | 3/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | RAB9A | P51151 | 8/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | USP2 | O75604 | 2/20 | 0.72 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.72 |
| ▸ | GAA | P10253 | 1/20 | 0.70 |
| ▸ | NPC1 | O15118 | 5/20 | 0.70 |
| ▸ | MEN1 | O00255 | 4/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 7/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11955292 | 0.94 | METAP2 (0.88) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL31452761 | 0.89 | METAP2 (0.97) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL9996355 | 0.88 | METAP2 (1.00) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL18719791 | 0.86 | METAP2 (0.75) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL1240342 | 0.85 | METAP2 (1.00) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL10037170 | 0.85 | METAP2 (0.74) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL12530781 | 0.84 | METAP2 (0.98) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL13391489 | 0.84 | MAPT (1.00) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL30506385 | 0.82 | MAPT (1.00) | METAP2KDM4EMAPTSMN1; SMN2HTT | |
| SCHEMBL27254064 | 0.82 | MAPT (1.00) | METAP2KDM4EMAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350012-B1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | UNIV JOHNS HOPKINS (US) | 2017-06-28 | — | — | EP | disclosed |
| US-8729097-B2 | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-05-20 | — | — | US | disclosed |
| US-20110301163-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-12-08 | — | — | US | disclosed |
| EP-2350012-A2 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | The Johns Hopkins University (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010042163-A2 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301163-A1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | SIRT1, SIRT2, SIRT3 | METAP2 9/4885KDM4E 997/4885MAPT 1913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.