Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 1.00 |
| ▸ | RAB9A | P51151 | 9/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 9/20 | 0.82 |
| ▸ | NPC1 | O15118 | 7/20 | 0.82 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.82 |
| ▸ | HTT | P42858 | 13/20 | 0.73 |
| ▸ | MAPT | P10636 | 11/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.73 |
| ▸ | LMNA | P02545 | 10/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | MPI | P34949 | 3/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 10/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530781 | 0.99 | METAP2 (0.98) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL11955292 | 0.91 | METAP2 (0.88) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL27253776 | 0.90 | L3MBTL1 (1.00) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL31452761 | 0.89 | METAP2 (0.97) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL1240789 | 0.89 | L3MBTL1 (0.80) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL9996355 | 0.88 | METAP2 (1.00) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL2312166 | 0.85 | METAP2 (1.00) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL12530869 | 0.84 | METAP2 (0.73) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL18719791 | 0.83 | METAP2 (0.75) | METAP2RAB9AL3MBTL1NPC1PAX8 | |
| SCHEMBL12905940 | 0.82 | METAP2 (0.70) | METAP2RAB9AL3MBTL1NPC1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2350012-B1 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | UNIV JOHNS HOPKINS (US) | 2017-06-28 | — | — | EP | disclosed |
| US-9012899-B2 | Electroluminescent metal complexes with nucleophilic carbene ligands | BASF SE (DE) | 2015-04-21 | — | — | US | disclosed |
| US-8906937-B2 | Flavivirus inhibitors and methods of their use | GEORGETOWN UNIVERSITY (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906937-B2 | Flavivirus inhibitors and methods of their use | GEORGETOWN UNIVERSITY (US) | 2014-12-09 | — | — | US | disclosed |
| US-8729097-B2 | Quinoline compounds as inhibitors of angiogenesis, human methionine aminopeptidase, and SIRT1, and methods of treating disorders | THE JOHNS HOPKINS UNIVERSITY (US) | 2014-05-20 | — | — | US | disclosed |
| US-20140038962-A1 | Flavivirus Inhibitors and Methods of Their Use | GEORGETOWN UNIVERSITY (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038962-A1 | Flavivirus Inhibitors and Methods of Their Use | GEORGETOWN UNIVERSITY (US) | 2014-02-06 | — | — | US | disclosed |
| US-20130292660-A1 | ELECTROLUMINESCENT METAL COMPLEXES WITH NUCLEOPHILIC CARBENE LIGANDS | BASF SE (DE) | 2013-11-07 | — | — | US | disclosed |
| US-8563580-B2 | Flavivirus inhibitors and methods for their use | GEORGETOWN UNIVERSITY (US) | 2013-10-22 | — | — | US | disclosed |
| US-8563580-B2 | Flavivirus inhibitors and methods for their use | GEORGETOWN UNIVERSITY (US) | 2013-10-22 | — | — | US | disclosed |
| US-20110224207-A1 | FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE | GEORGETOWN UNIVERSITY (US) | 2011-09-15 | — | — | US | disclosed |
| EP-2350012-A2 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | The Johns Hopkins University (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20110114922-A1 | Electroluminescent Metal Complexes with Nucleophilic Carbene Ligands | UDC IRELAND LIMITED (IE) | 2011-05-19 | — | — | US | disclosed |
| WO-2011020886-A1 | NOVEL QUINOLINE-HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-02-24 | — | — | WO | disclosed |
| WO-2010042163-A2 | QUINOLINE COMPOUNDS AS INHIBITORS OF ANGIOGENESIS, HUMAN METHIONINE AMINOPEPTIDASE, AND SIRT1, AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010039538-A2 | FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE | GEORGETOWN UNIVERSITY (US) | 2010-04-08 | — | — | WO | disclosed |
| EP-2080796-A1 | Electroluminescent metal complexes with nucleophilic carbene ligands | Ciba Holding Inc. (CH) | 2009-07-22 | — | — | EP | disclosed |
| CN-101087863-A | Electroluminescent metal complexes with nucleophilic carbene ligands | CIBA SC HOLDING AG (CH) | 2007-12-12 | — | — | CN | disclosed |
| EP-1841834-A1 | ELECTROLUMINESCENT METAL COMPLEXES WITH NUCLEOPHILIC CARBENE LIGANDS | Ciba Specialty Chemicals Holding Inc. (CH) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006067074-A1 | ELECTROLUMINESCENT METAL COMPLEXES WITH NUCLEOPHILIC CARBENE LIGANDS | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224207-A1 | FLAVIVIRUS INHIBITORS AND METHODS FOR THEIR USE | SERPINB1, SPINT2, MME | METAP2 71/4885RAB9A 2084/4885L3MBTL1 1524/4885 |
| US-20110114922-A1 | Electroluminescent Metal Complexes with Nucleophilic Carbene Ligands | OCIAD1, OCIAD2, C1S | METAP2 4435/4885RAB9A 3166/4885L3MBTL1 96/4885 |
| US-20140038962-A1 | Flavivirus Inhibitors and Methods of Their Use | SERPINB1, SPINT2, MME | METAP2 57/4885RAB9A 2277/4885L3MBTL1 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.