Sugi Predict

Sugi Predict / Compounds / SCHEMBL231271

SCHEMBL231271

SCHEMBL231271

[CH2]CCCN1CCOCC1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KEAP1 Q14145 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60
▸ HPGD P15428 1/20 0.48
▸ DUSP3 P51452 1/20 0.48
▸ ALDH1A1 P00352 2/20 0.48
▸ KDM4E B2RXH2 2/20 0.48
▸ SIGMAR1 Q99720 3/20 0.47
▸ POLB P06746 1/20 0.47
▸ GLA P06280 1/20 0.43
▸ MAPK1 P28482 2/20 0.43
▸ GAA P10253 1/20 0.43
▸ CYP1A2 P05177 1/20 0.43
▸ CHRM2 P08172 1/20 0.43
▸ CHRM1 P11229 1/20 0.43
▸ HTR2A P28223 1/20 0.43
▸ SCN1A P35498 1/20 0.43
▸ HTR2B P41595 1/20 0.43
▸ KCNH2 Q12809 1/20 0.43
▸ SCN2A Q99250 1/20 0.43
▸ SCN3A Q9NY46 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL232859 0.93 KEAP1 (0.58) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL232389 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL7670406 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL230211 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL5390103 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL231117 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL233216 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL231245 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL10889066 0.91 KEAP1 (0.56) KEAP1SMN1; SMN2HPGDDUSP3ALDH1A1
SCHEMBL5154 0.84 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117843566-A Polysubstituted benzene derivative, composition and use thereof 康迈迪森(北京)医药科技有限公司 2024-04-09 — — CN claimed
CN-117050043-A 3-phenyl dibenzofuran compound and preparation method and application thereof 中国海洋大学 2023-11-14 — — CN claimed
CN-116751200-A Tricyclic compounds containing substituted pyridones and methods of using the same 爱彼特生物制药公司 2023-09-15 — — CN claimed
CN-110114071-B Tricyclic compounds containing substituted pyridones and methods of using the same 爱彼特生物制药公司 2023-07-04 — — CN claimed
CN-108948019-B Focal adhesion kinase inhibitors and uses thereof 广东东阳光药业有限公司 2022-07-08 — — CN claimed
CN-112898286-A Benzothiophene compound or pharmaceutically acceptable salt and isomer thereof, and preparation method, pharmaceutical composition and application thereof 中国药科大学 2021-06-04 — — CN claimed
US-11013726-B2 Substituted pyridinone-containing trycyclic compounds, and methods using same ARBUTUS BIOPHARMA CORPORATION (CA) 2021-05-25 — — US claimed
US-20200261432-A1 SUBSTITUTED PYRIDINONE-CONTAINING TRYCYCLIC COMPOUNDS, AND METHODS USING SAME ARBUTUS BIOPHARMA CORPORATION (CA) 2020-08-20 — — US claimed
CN-110862397-A Dioxane quinazoline and dioxane quinoline compounds, and preparation method and application thereof 北京赛特明强医药科技有限公司 2020-03-06 — — CN claimed
WO-2020015716-A1 IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF BETTA PHARMACEUTICALS CO., LTD (CN) 2020-01-23 — — WO claimed
EP-0166682-B1 PROCESS FOR OBTAINING POSITIVE IMAGES CIBA-GEIGY AG (CH) 1992-01-08 — — EP claimed
EP-0233151-B1 ESTERS AS HERBICIDES CIBA-GEIGY AG (CH) 1991-11-13 — — EP claimed
US-4958024-A REACTION OF CARBAMATE SUBSTITUTED ACRYLIC ESTER, VASODILATORS, HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL COMPANY, LTD. (JP) 1990-09-18 — — US claimed
US-4914227-A FOR VASODILATING AND HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL COMPANY, LTD. (JP) 1990-04-03 — — US claimed
US-4739106-A VASODILATION, HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL CO., LTD. (JP) 1988-04-19 — — US claimed
EP-0101023-B1 PROCESS FOR PREPARING 2-CARBAMOYLOXYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND INTERMEDIATES USEFUL FOR THE PROCESS BANYU PHARMACEUTICAL CO., LTD. (JP) 1987-07-29 — — EP claimed
EP-0024259-B1 DERIVATIVES OF 5-(PYRIDYL-2-OXY)-2-NITROBENZOIC ACID, THEIR PREPARATION AND HERBICIDAL COMPOSITIONS CONTAINING THEM CIBA-GEIGY AG (CH) 1985-07-31 — — EP claimed
EP-0101023-A1 Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process BANYU PHARMACEUTICAL CO., LTD. (JP) 1984-02-22 — — EP claimed
US-4410536-A 7,8,9,10-Tetrahydrothieno[3,2-e]pyrido[4,3-b]indole compounds and their anti-depressant use TROPONWERKE GMBH & CO. K.G. (DE) 1983-10-18 — — US claimed
EP-0000176-B1 PYRIDYLOXY-PHENOXY-ALKANOIC ACID DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES OR PLANT GROWTH REGULATORS CIBA-GEIGY AG (CH) 1981-09-16 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200261432-A1 SUBSTITUTED PYRIDINONE-CONTAINING TRYCYCLIC COMPOUNDS, AND METHODS USING SAME HAVCR2, HCCS, TYMP KEAP1 1244/4885SMN1; SMN2 4376/4885HPGD 393/4885
US-11013726-B2 Substituted pyridinone-containing trycyclic compounds, and methods using same HAVCR2, HCCS, TYMP KEAP1 1244/4885SMN1; SMN2 4376/4885HPGD 393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.