Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 14/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21167343 | 0.74 | MET (0.44) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL14378441 | 0.74 | MET (0.59) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167339 | 0.73 | MET (0.43) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL23127990 | 0.72 | NOS3 (0.33) | — | |
| SCHEMBL23128022 | 0.72 | MET (0.46) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24590989 | 0.68 | MET (0.43) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167690 | 0.67 | MET (0.41) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL24591101 | 0.66 | MET (0.38) | METFGFR1FGFR3KDRFGFR2 | |
| SCHEMBL21167489 | 0.66 | MET (0.40) | METPDE3BPDE3ACYP2C9PDE10A | |
| SCHEMBL21167736 | 0.66 | MET (0.41) | METPDE3BPDE3ACYP2C9PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3795573-A1 | CERTAIN TRIAZOLOPYRIDINES AND TRIAZOLOPYRIDINES, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR | Hutchison Medipharma Limited (CN) | 2021-03-24 | — | — | EP | disclosed |