Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | SI | P14410 | 3/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HAT1 | O14929 | 5/20 | 0.31 |
| ▸ | EP300 | Q09472 | 5/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | GUSB | P08236 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313591 | 1.00 | SLC6A2 (0.33) | SLC6A2ROCK2ROCK1MAPK10MGAM | |
| SCHEMBL2805932 | 0.91 | SLC6A2 (0.36) | SLC6A2ROCK2ROCK1MGAMGAA | |
| SCHEMBL2805929 | 0.91 | SLC6A2 (0.36) | SLC6A2ROCK2ROCK1MGAMGAA | |
| SCHEMBL2314771 | 0.91 | PDCD1 (0.32) | SLC6A2ROCK2ROCK1HAT1EP300 | |
| SCHEMBL2308881 | 0.91 | SCN9A (0.36) | ROCK2ROCK1MGAMGAASI | |
| SCHEMBL2312747 | 0.91 | MGAM (0.33) | SLC6A2MGAMGAASIMGAM2 | |
| SCHEMBL2312740 | 0.91 | MGAM (0.33) | SLC6A2MGAMGAASIMGAM2 | |
| SCHEMBL2313596 | 0.90 | ROCK2 (0.36) | ROCK2ROCK1HAT1EP300B3GNT2 | |
| SCHEMBL2313639 | 0.89 | SLC6A2 (0.37) | SLC6A2MGAMGAASIMGAM2 | |
| SCHEMBL2313642 | 0.89 | SLC6A2 (0.37) | SLC6A2MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150556-B2 | Benzimidazolone chymase inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| EP-2152674-B1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2011-08-03 | — | — | EP | disclosed |
| US-20100240702-A1 | Benzimidazolone Chymase Inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240702-A1 | Benzimidazolone Chymase Inhibitors | CMA1, SERPINB1, CPA3 | SLC6A2 4187/4885ROCK2 2645/4885ROCK1 2407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.