Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2311050 | 0.84 | KIT (0.49) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL9737173 | 0.82 | KIT (0.53) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL2311605 | 0.77 | KIT (0.54) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL2308783 | 0.73 | KIT (0.59) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL2311857 | 0.73 | KIT (0.65) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL2308791 | 0.73 | KIT (0.55) | MAPTKITKDM4EMEN1NR3C1 | |
| Pazelliptine SCHEMBL62441 | 0.71 | KIT (0.73) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL12387163 | 0.71 | KIT (0.61) | MAPTKITKDM4EMEN1NR3C1 | |
| Pazelliptine SCHEMBL1230910 | 0.71 | KIT (0.72) | MAPTKITKDM4EMEN1NR3C1 | |
| SCHEMBL3342543 | 0.70 | KIT (0.72) | MAPTKITKDM4EMEN1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989467-B2 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-08-02 | — | — | US | claimed |
| US-20070054905-A1 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-03-08 | — | — | US | claimed |
| US-7989467-B2 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-08-02 | — | — | US | disclosed |
| US-7989467-B2 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-08-02 | — | — | US | disclosed |
| US-7989467-B2 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2011-08-02 | — | — | US | disclosed |
| US-20070054905-A1 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-03-08 | — | — | US | disclosed |
| US-20070054905-A1 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-03-08 | — | — | US | disclosed |
| US-20070054905-A1 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054905-A1 | Use of indole-derived compounds for the preparation of a medicament that can be used to treat diseases related to the splicing process | RBM17, BRCA1, SMN1; SMN2 | MAPT 238/4885KIT 2116/4885KDM4E 2967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.