Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
| ▸ | FLT3 | P36888 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.49 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.49 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189458 | 0.81 | GRIA1 (0.54) | GSK3BROCK2CSF1RKDRFLT3 | |
| SCHEMBL18189616 | 0.80 | GRIA1 (0.58) | GSK3BROCK2CSF1RKDRFLT3 | |
| SCHEMBL4406924 | 0.79 | CHEK1 (0.58) | KDRCRBNBRD4CREBBPGRIA1 | |
| SCHEMBL18189346 | 0.79 | GRIA1 (0.54) | GSK3BROCK2CSF1RKDRFLT3 | |
| SCHEMBL5782680 | 0.77 | GRIA1 (0.78) | GSK3BCDK5CRBNBRD4CREBBP | |
| SCHEMBL29849951 | 0.77 | CRBN (0.51) | CRBNBRD4CREBBPGRIA1CACNG8 | |
| SCHEMBL1359221 | 0.76 | CRBN (0.59) | GSK3BCRBNCCNB2CDK1CCNB1 | |
| SCHEMBL29374811 | 0.76 | CRBN (0.59) | GSK3BCRBNCCNB2CDK1CCNB1 | |
| SCHEMBL29295035 | 0.74 | SLC6A3 (0.64) | GSK3BROCK2CSF1RKDRFLT3 | |
| SCHEMBL10710464 | 0.74 | GRIA1 (0.54) | CRBNBRD4CREBBPGRIA1CACNG8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11542274-B1 | Therapeutic compounds and methods of use thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2023-01-03 | — | — | US | disclosed |
| US-11542274-B1 | Therapeutic compounds and methods of use thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2023-01-03 | — | — | US | disclosed |
| CN-114929670-A | Therapeutic compounds and methods of use thereof | 新加坡科技研究局 | 2022-08-19 | — | — | CN | disclosed |
| EP-4034526-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Agency for Science, Technology and Research (A*STAR) (SG) | 2022-08-03 | — | — | EP | disclosed |
| US-20210147441-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-05-20 | — | — | US | disclosed |
| US-20210147441-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-05-20 | — | — | US | disclosed |
| WO-2021061053-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-04-01 | — | — | WO | disclosed |
| WO-2021061053-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR) (SG) | 2021-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210147441-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | UBQLN2, TXNRD1, TXNRD2 | GSK3B 3807/4885ROCK2 3167/4885CSF1R 3601/4885 |
| US-11542274-B1 | Therapeutic compounds and methods of use thereof | MDM2, SUMO2, XIAP | GSK3B 2893/4885ROCK2 2556/4885CSF1R 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.