Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26789763 | 0.76 | HTT (0.55) | SMN1; SMN2KMT2AMEN1GAAGSK3A | |
| SCHEMBL15432249 | 0.74 | SMN1; SMN2 (0.50) | L3MBTL1ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL21059189 | 0.71 | SMN1; SMN2 (0.68) | L3MBTL1ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL23155544 | 0.71 | NAMPT (0.46) | ALDH1A1SMN1; SMN2GAAGSK3AGSK3B | |
| SCHEMBL3655456 | 0.70 | SMN1; SMN2 (0.55) | L3MBTL1ALDH1A1CYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL23944960 | 0.69 | L3MBTL1 (0.66) | L3MBTL1ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL21634990 | 0.68 | UCHL1 (0.35) | L3MBTL1ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL21059187 | 0.68 | L3MBTL1 (0.63) | L3MBTL1ALDH1A1LMNATSHRNPSR1 | |
| SCHEMBL26804292 | 0.68 | HTT (0.44) | ALDH1A1SMN1; SMN2GSK3AGSK3BKDM4E | |
| SCHEMBL24761938 | 0.68 | NPC1 (0.54) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021061643-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-04-01 | — | — | WO | disclosed |