Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.32 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320310 | 0.86 | LATS1 (0.37) | PTGS1PTGS2PTGDR2ALDH3A1LATS1 | |
| SCHEMBL2318455 | 0.83 | PTGDR2 (0.34) | PTGDR2LATS1L3MBTL1LMNABRD4 | |
| SCHEMBL16244938 | 0.83 | PTGDR2 (0.42) | PTGDR2LATS1L3MBTL1BRD4 | |
| SCHEMBL2322259 | 0.82 | PTGDR2 (0.39) | PTGDR2ALDH3A1LATS1L3MBTL1NOD1 | |
| SCHEMBL2316775 | 0.82 | GAA (0.35) | PTGDR2ALDH3A1LATS1L3MBTL1NOD1 | |
| SCHEMBL2318104 | 0.82 | PTGDR2 (0.36) | PTGDR2ALDH3A1LATS1PKMNPC1 | |
| SCHEMBL2315327 | 0.81 | LMNA (0.43) | PTGDR2ALDH3A1LMNABRD4ALDH1A1 | |
| SCHEMBL2319229 | 0.81 | LATS1 (0.35) | PTGDR2ALDH3A1LATS1L3MBTL1NOD1 | |
| SCHEMBL1932988 | 0.81 | PCSK9 (0.35) | PTGDR2ALDH3A1LMNASCN9ABRD4 | |
| SCHEMBL2319349 | 0.81 | MAPT (0.41) | PTGS1PTGS2PTGDR2L3MBTL1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785639-B2 | Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof | ABBVIE INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20110190489-A1 | Novel Tricyclic Compounds | ABBOTT LABORATORIES (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190489-A1 | Novel Tricyclic Compounds | CCNI, IL2, IL4I1 | PTGS1 162/4885PTGS2 167/4885PTGDR2 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.