Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 5/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.33 |
| ▸ | EED | O75530 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.32 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2314750 | 0.82 | PTGS1 (0.37) | GAAALDH1A1PTGDR2ALDH3A1PSEN1 | |
| SCHEMBL16244938 | 0.81 | PTGDR2 (0.42) | GSK3BPTGDR2LATS1PCSK9L3MBTL1 | |
| SCHEMBL2322259 | 0.80 | PTGDR2 (0.39) | GAASMN1; SMN2PTGDR2ALDH3A1LATS1 | |
| SCHEMBL2317803 | 0.80 | PCSK9 (0.38) | GAAALDH1A1PTGDR2ALDH3A1EED | |
| SCHEMBL2319238 | 0.80 | CYP11B1 (0.39) | SMN1; SMN2PTGDR2LATS1CYP3A4CYP2C9 | |
| SCHEMBL2320310 | 0.78 | LATS1 (0.37) | GAAALDH1A1SMN1; SMN2PTGDR2ALDH3A1 | |
| SCHEMBL2318455 | 0.78 | PTGDR2 (0.34) | ALDH1A1SMN1; SMN2PTGDR2LATS1PCSK9 | |
| SCHEMBL4357924 | 0.77 | ACVR1 (0.38) | PTGDR2PIK3CANOD2CYP2C9HTT | |
| SCHEMBL2315157 | 0.77 | LMNA (0.37) | ALDH1A1PTGDR2ALDH3A1LATS1CYP3A4 | |
| SCHEMBL2318104 | 0.77 | PTGDR2 (0.36) | GAAALDH1A1PTGDR2ALDH3A1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140349970-A1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC. (US) | 2014-11-27 | — | — | US | disclosed |
| US-8785639-B2 | Substituted dihydropyrazolo[3,4-D]pyrrolo[2,3-B]pyridines and methods of use thereof | ABBVIE INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20110190489-A1 | Novel Tricyclic Compounds | ABBOTT LABORATORIES (US) | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140349970-A1 | NOVEL TRICYCLIC COMPOUNDS | CCNI, IL2, IL4I1 | GAA 2251/4885ALDH1A1 305/4885SMN1; SMN2 4280/4885 |
| US-20110190489-A1 | Novel Tricyclic Compounds | CCNI, IL2, IL4I1 | GAA 2251/4885ALDH1A1 305/4885SMN1; SMN2 4280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.