Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22743009 | 0.87 | KEAP1 (0.46) | DHODHGRIN1GRIN2AGRIN2BGRIN2C | |
| SCHEMBL29253558 | 0.83 | MAPT (0.51) | RXFP1ALDH1A1POLBMAPTHPGD | |
| SCHEMBL30682029 | 0.83 | ALDH1A1 (0.50) | DHODHGPR35KEAP1NFE2L2MEN1 | |
| SCHEMBL2310035 | 0.83 | ALDH1A1 (0.50) | DHODHGPR35KEAP1NFE2L2MEN1 | |
| SCHEMBL7266030 | 0.81 | L3MBTL1 (0.53) | RXFP1KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL26617507 | 0.80 | KEAP1 (0.54) | DHODHKEAP1NFE2L2MEN1KMT2A | |
| SCHEMBL16945099 | 0.80 | KMT2A (0.71) | DHODHMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL2312424 | 0.78 | ALDH1A1 (0.57) | MEN1KMT2ARXFP1KDM4EALDH1A1 | |
| SCHEMBL31105819 | 0.77 | HTT (0.54) | KEAP1NFE2L2MEN1KMT2AKDM4E | |
| SCHEMBL529351 | 0.77 | HTT (0.54) | KEAP1NFE2L2MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288549-B2 | Glycine B antagonist | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20110190342-A1 | GLYCINE B ANTAGONIST | HENRICH MARKUS | 2011-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190342-A1 | GLYCINE B ANTAGONIST | GRIN2B, GLRB, GRIN2A | DHODH 1439/4885GRIN1 11/4885GRIN2A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.