Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | NOX1 | Q9Y5S8 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19250960 | 0.86 | HTR1A (0.38) | HTR1AHDAC1HDAC2IDO1AGXT | |
| SCHEMBL23157787 | 0.86 | IDO1 (0.53) | CYP3A4IDO1AGXT | |
| SCHEMBL16749885 | 0.82 | PDE4A (0.43) | HTR1APDE4ASLC6A3NOX1SIGMAR1 | |
| SCHEMBL19240348 | 0.82 | HTR1A (0.39) | HTR1AHDAC1HDAC2PDE4ACYP3A4 | |
| SCHEMBL14270237 | 0.79 | SIGMAR1 (0.44) | HTR1AIDO1NOX1SIGMAR1NOS1 | |
| SCHEMBL23270659 | 0.79 | HTR1A (0.40) | TSHRHTR1APDE4ASLC6A3NOX1 | |
| SCHEMBL15617807 | 0.79 | HTR1A (0.43) | HTR1APDE4ASLC6A3NOX1SIGMAR1 | |
| SCHEMBL20552581 | 0.79 | NOS1 (0.53) | NOS1NOS2 | |
| SCHEMBL17208761 | 0.79 | HTR1A (0.40) | TSHRHTR1APDE4ASLC6A3NOX1 | |
| SCHEMBL15617804 | 0.79 | NOS1 (0.49) | TSHRHTR1APDE4ASLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. | 2021-04-01 | — | — | US | disclosed |
| CN-110770243-A | Rapamycin analogs as MTOR inhibitors | 锐新医药公司 | 2020-02-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094975-A1 | RAPAMYCIN ANALOGS AS MTOR INHIBITORS | MTOR, RICTOR, RPTOR | TSHR 3837/4885HTR1A 3445/4885HDAC1 516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.