Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 6/20 | 0.46 |
| ▸ | CNR1 | P21554 | 5/20 | 0.45 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323579 | 0.84 | CNR1 (0.47) | CNR2CNR1EPHX2 | |
| SCHEMBL2316495 | 0.81 | POLB (0.55) | POLBCNR2CNR1FAAHHPGD | |
| SCHEMBL2318742 | 0.75 | ALDH1A1 (0.53) | CNR1FAAH | |
| SCHEMBL1420777 | 0.73 | FAAH (0.61) | CNR2FAAHEPHX2MEN1KMT2A | |
| SCHEMBL2318297 | 0.73 | HTT (0.35) | CNR2CNR1FAAHEPHX2 | |
| SCHEMBL2320470 | 0.72 | TDP1 (0.52) | EPHX2 | |
| SCHEMBL2315297 | 0.72 | MEN1 (0.48) | CNR2CNR1EPHX2MEN1KMT2A | |
| SCHEMBL16908728 | 0.72 | POLB (0.43) | POLBEPHX2 | |
| SCHEMBL14263139 | 0.71 | CNR2 (0.50) | POLBCNR2CNR1PIN1 | |
| SCHEMBL2316419 | 0.69 | P2RX7 (0.57) | CNR2CNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928840-B1 | 1H-Pyrazole-4-carboxamides, their preparation and their use as 11-beta-hydroxysteroid dehydrogenase inhibitors | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | claimed |