Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | PTAFR | P25105 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23144014 | 0.86 | LRRK2 (0.47) | LRRK2KMT2AALDH1A1PTAFRSMN1; SMN2 | |
| SCHEMBL31269821 | 0.86 | LRRK2 (0.47) | LRRK2KMT2AALDH1A1PTAFRSMN1; SMN2 | |
| SCHEMBL31363915 | 0.77 | SMN1; SMN2 (0.51) | KMT2AALDH1A1HTTSMN1; SMN2PKM | |
| SCHEMBL23144748 | 0.77 | TOP2B (0.48) | LRRK2ALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL30870921 | 0.77 | SMN1; SMN2 (0.51) | KMT2AALDH1A1HTTSMN1; SMN2PKM | |
| SCHEMBL23144232 | 0.74 | LRRK2 (0.35) | LRRK2MEN1KMT2AHTTLMNA | |
| SCHEMBL29812116 | 0.74 | LRRK2 (0.35) | LRRK2MEN1KMT2AHTTLMNA | |
| SCHEMBL31364019 | 0.73 | IDH1 (0.51) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL15478495 | 0.70 | MEN1 (0.57) | MEN1KMT2AALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL23144259 | 0.70 | CA2 (0.55) | ALDH1A1LMNAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021061643-A1 | METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION | PMV PHARMACEUTICALS, INC. (US) | 2021-04-01 | — | — | WO | disclosed |