Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.33 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23161917 | 0.90 | ADORA3 (0.41) | KCNH2ADORA3GUCY1A1GUCY1B1ALDH1A1 | |
| SCHEMBL28504551 | 0.90 | ADORA3 (0.37) | KCNH2ADORA3P2RX7PTGDR2TLR7 | |
| SCHEMBL23186726 | 0.86 | ADORA3 (0.41) | KCNH2ADORA3P2RX7TLR7HDAC1 | |
| SCHEMBL23162006 | 0.86 | GUCY1A1 (0.42) | P2RX7PTGDR2GUCY1A1GUCY1B1IDO1 | |
| SCHEMBL23161951 | 0.85 | KCNH2 (0.49) | KCNH2ADORA3GUCY1A1GUCY1B1 | |
| SCHEMBL23186716 | 0.84 | KCNH2 (0.57) | KCNH2ADORA3P2RX7TLR7GUCY1A1 | |
| SCHEMBL23161934 | 0.83 | ALDH1A1 (0.40) | KCNH2ADORA3P2RX7TLR7ALDH1A1 | |
| SCHEMBL23162034 | 0.83 | ADORA3 (0.37) | KCNH2ADORA3P2RX7PTGDR2TLR7 | |
| SCHEMBL23161989 | 0.82 | KCNH2 (0.45) | KCNH2ADORA3PTGDR2GUCY1A1GUCY1B1 | |
| SCHEMBL23161925 | 0.81 | ADORA3 (0.39) | KCNH2ADORA3GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609883-B1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2022-06-29 | — | — | EP | disclosed |
| US-11242335-B2 | Fluorine-substituted indazole compounds and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2022-02-08 | — | — | US | disclosed |
| US-20210101882-A1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-04-08 | — | — | US | disclosed |
| CN-108727340-B | Fluorine substituted indazoles and use thereof | 广东东阳光药业有限公司 | 2020-12-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11242335-B2 | Fluorine-substituted indazole compounds and uses thereof | GUCY1B2, GUCY1A2, PDE3A | KCNH2 485/4885ADORA3 46/4885P2RX7 558/4885 |
| US-20210101882-A1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | PDE3A, PDE3B, PDE5A | KCNH2 835/4885ADORA3 43/4885P2RX7 352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.