Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 7/20 | 0.59 |
| ▸ | CA2 | P00918 | 7/20 | 0.59 |
| ▸ | CA9 | Q16790 | 6/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CTRC | Q99895 | 1/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19451062 | 1.00 | CA12 (0.59) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL29615332 | 1.00 | CA12 (0.59) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL2317419 | 1.00 | CA12 (0.59) | CA12CA2CA9KDM4ESIRT2 | |
| Alcohol SCHEMBL28211826 | 0.90 | CA12 (0.55) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL20338550 | 0.82 | CA12 (0.51) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL2316674 | 0.82 | POLB (0.69) | CA2KDM4ESIRT2GAAL3MBTL1 | |
| Sebacic Acid SCHEMBL27952310 | 0.81 | CA12 (0.50) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL28035152 | 0.81 | CA12 (0.50) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL5605340 | 0.80 | RAB9A (0.67) | CA12CA2CA9KDM4ESIRT2 | |
| SCHEMBL29735007 | 0.80 | RAB9A (0.67) | CA12CA2CA9KDM4ESIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110759833-B | Preparation method and application of 4-hydroxy-benzyl (2' -hydroxy-benzylidene) -hydrazide | 国家林业和草原局竹子研究开发中心 | 2022-06-14 | — | — | CN | claimed |
| CN-110759833-A | Preparation method and application of 4-hydroxy-benzyl (2' -hydroxy-benzylidene) -hydrazide | 国家林业和草原局竹子研究开发中心 | 2020-02-07 | — | — | CN | claimed |
| EP-1392219-A4 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOTOSIS AND THE USE THEREOF | CYTOVIA INC (US) | 2007-01-24 | — | — | EP | claimed |
| US-20040186078-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2004-09-23 | — | — | US | claimed |
| US-6716859-B2 | ANTICANCER AGENTS | CYTOVIA, INC. | 2004-04-06 | — | — | US | claimed |
| EP-1392219-A2 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOTOSIS AND THE USE THEREOF | Cytovia, Inc. (US) | 2004-03-03 | — | — | EP | claimed |
| US-20030105140-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2003-06-05 | — | — | US | claimed |
| US-20030013743-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2003-01-16 | — | — | US | claimed |
| WO-2002102301-A2 | SUBSTITUTED INDOLE-2-CARBOXYLIC ACID BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-12-27 | — | — | WO | claimed |
| WO-2002089745-A2 | SUBSTITUTED N'-(ARYLCARBONYL)-BENZHYDRAZIDES, N'-(ARYLCARBONYL)-BENZYLIDENE-HYDRAZIDES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | CYTOVIA, INC. (US) | 2002-11-14 | — | — | WO | claimed |
| US-20020128292-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CYTOVIA, INC. | 2002-09-12 | — | — | US | claimed |
| EP-0661357-B1 | Polymeric pigment dispersants for use in coating compositions | BASF CORP (US) | 2001-10-31 | — | — | EP | claimed |
| CN-115677554-B | Aggregation-induced emission-based 3, 4-disulfide maleimide derivative fluorescent molecule, and preparation method and application thereof | 巢湖学院 | 2025-03-18 | — | — | CN | disclosed |
| CN-115677554-A | 3,4-dithioether maleimide derivative fluorescent molecule based on aggregation-induced emission, and preparation method and application thereof | 巢湖学院 | 2023-02-03 | — | — | CN | disclosed |
| CN-113402417-B | Zinc-aluminum ion recognition fluorescent probe and preparation method and application thereof | 上海交通大学医学院附属瑞金医院 | 2023-01-03 | — | — | CN | disclosed |
| CN-115458164-A | Prostate health index evaluation model and construction method and evaluation method thereof | 上海微创惟微诊断技术有限公司 | 2022-12-09 | — | — | CN | disclosed |
| US-4767692-A | NUCLEATING AGENT WITH UREA AND HYDRAZIDE GROUPS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-08-30 | — | — | US | disclosed |
| US-4737452-A | WITH AROMATIC COMPOUND CONTAINING MERCAPTO AND HYDROZIDE GROUPS | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-12 | — | — | US | disclosed |
| EP-0154293-A2 | Silver halide photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1985-09-11 | — | — | EP | disclosed |
| EP-0053098-A2 | Alkanol-amine esters of cyclic 1,1'-biphenyl-2,2'-diyl and alkylidene-1,1'-biphenyl-2,2'-diyl phosphites | CIBA-GEIGY AG (CH) | 1982-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128292-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | BAD, API5, CASP2 | CA12 584/4885CA2 123/4885CA9 704/4885 |
| US-20030105140-A1 | Substituted indole-2-carboxylic acid benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | BAD, API5, CASP2 | CA12 584/4885CA2 123/4885CA9 704/4885 |
| US-20040186078-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP2, CASP1, BCL2 | CA12 3756/4885CA2 744/4885CA9 2544/4885 |
| US-20030013743-A1 | Substituted N'-(arylcarbonyl)-benzhydrazides, N'-(arylcarbonyl)-benzylidene-hydrazides and analogs as activators of caspases and inducers of apoptosis and the use thereof | CASP2, CASP1, BCL2 | CA12 3756/4885CA2 744/4885CA9 2544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.