Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PLTP | P55058 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2313698 | 0.90 | PLTP (0.49) | LMNAALDH1A1KDM4EPOLBPLTP | |
| SCHEMBL2488862 | 0.89 | LMNA (0.56) | LMNAALDH1A1KDM4EPOLBPLTP | |
| SCHEMBL2316402 | 0.85 | PLTP (0.51) | ALDH1A1KDM4EPLTPADORA1ADORA2A | |
| SCHEMBL2318436 | 0.85 | PLTP (0.50) | ALDH1A1KDM4EPLTPADORA1ADORA2A | |
| SCHEMBL2315059 | 0.85 | PLTP (0.47) | LMNAALDH1A1KDM4EPOLBPLTP | |
| SCHEMBL2316605 | 0.84 | ADORA1 (0.52) | ALDH1A1PLTPADORA1ADORA2AADORA3 | |
| SCHEMBL2320700 | 0.84 | PLTP (0.49) | ALDH1A1PLTPADORA1ADORA2AADORA3 | |
| SCHEMBL2317599 | 0.84 | PLTP (0.49) | LMNAKDM4EPLTPADORA1ADORA3 | |
| SCHEMBL2314988 | 0.84 | TRPV4 (0.54) | KDM4EPLTPADORA1ADORA3RORC | |
| SCHEMBL2319840 | 0.83 | PLTP (0.48) | ALDH1A1KDM4EPLTPADORA1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2349484-A2 | HETEROARYL DERIVATIVES AS DGAT1 INHIBITORS | Novartis AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010007046-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2010-01-21 | — | — | WO | disclosed |