Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23383717 | 0.83 | ATF4 (0.49) | ATF4KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21390276 | 0.80 | ATF4 (0.53) | ATF4KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL22956668 | 0.79 | TDP1 (0.52) | ATF4KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL20582511 | 0.77 | ATF4 (0.84) | ATF4MEN1KMT2A | |
| SCHEMBL23182732 | 0.73 | HTT (0.52) | KDM4ECYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL22669498 | 0.73 | MEN1 (0.67) | ATF4KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL3183655 | 0.72 | ALDH1A1 (0.54) | HTTSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL16082992 | 0.72 | KMT2A (0.66) | ATF4KDM4EHTTSMN1; SMN2MEN1 | |
| SCHEMBL10090423 | 0.72 | RAB9A (0.70) | ATF4KDM4ECYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21621101 | 0.71 | KDM4E (0.56) | ATF4KDM4ECYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210093619-A1 | Chemical Compounds as ATF-4 Pathway Inhibitors | ATF4, ATF1, XBP1 | ATF4 1/4885KDM4E 2914/4885CYP1A2 2879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.