Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20350431 | 0.86 | MAPT (0.37) | NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL17646572 | 0.86 | MEN1 (0.38) | LMNASMN1; SMN2CRHR1MEN1GAA | |
| SCHEMBL17648477 | 0.85 | NNMT (0.38) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL29917985 | 0.85 | NNMT (0.38) | F10NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL17649319 | 0.82 | FLT1 (0.48) | FLT1FLT4KDRMEN1KMT2A | |
| SCHEMBL29918097 | 0.81 | PTGS2 (0.48) | LMNAFLT1FLT4KDRMEN1 | |
| SCHEMBL17646596 | 0.81 | PTGS2 (0.48) | LMNAFLT1FLT4KDRMEN1 | |
| SCHEMBL29917505 | 0.81 | FLT1 (0.47) | LMNASMN1; SMN2FLT1FLT4KDR | |
| SCHEMBL17648576 | 0.81 | FLT1 (0.47) | LMNASMN1; SMN2FLT1FLT4KDR | |
| SCHEMBL17648398 | 0.80 | FLT1 (0.41) | NPC1LMNARAB9AFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3798214-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2021-03-31 | — | — | EP | disclosed |