Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3455318 | 1.00 | TDP1 (0.37) | TDP1L3MBTL1EPHX2NPSR1KMT2A | |
| SCHEMBL12308355 | 0.77 | RET (0.35) | TDP1L3MBTL1EPHX2 | |
| SCHEMBL27874091 | 0.72 | TDP1 (0.34) | TDP1L3MBTL1NPSR1 | |
| SCHEMBL11272711 | 0.68 | NPSR1 (0.35) | EPHX2NPSR1KMT2AMAPTMAPK1 | |
| SCHEMBL19005981 | 0.68 | NPSR1 (0.35) | EPHX2NPSR1KMT2AMAPTMAPK1 | |
| SCHEMBL11272713 | 0.68 | NPSR1 (0.35) | EPHX2NPSR1KMT2AMAPTMAPK1 | |
| SCHEMBL3455322 | 0.67 | CHRNB2 (0.33) | KMT2AMAPTMAPK1ALDH1A1MEN1 | |
| SCHEMBL654309 | 0.66 | EPHX2 (0.40) | EPHX2KMT2AMAPTMAPK1ALDH1A1 | |
| Methacrylic Acid SCHEMBL10543747 | 0.64 | EPHX2 (0.40) | EPHX2NPSR1KMT2AMAPTMAPK1 | |
| SCHEMBL12308356 | 0.64 | NPSR1 (0.33) | EPHX2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928840-B1 | 1H-Pyrazole-4-carboxamides, their preparation and their use as 11-beta-hydroxysteroid dehydrogenase inhibitors | HOFFMANN LA ROCHE (CH) | 2011-08-10 | — | — | EP | claimed |