Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ethambutol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CNR1 | P21554 | 1/20 | 0.68 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.68 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ENPEP | Q07075 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethambutol SCHEMBL2319449 | 0.86 | LMNA (0.71) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL8575513 | 0.85 | LMNA (0.77) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL29131237 | 0.85 | LMNA (0.77) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL2342754 | 0.83 | LMNA (0.81) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL2961583 | 0.82 | LMNA (1.00) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL4029 | 0.82 | LMNA (1.00) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL15479016 | 0.82 | LMNA (1.00) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL2636850 | 0.82 | LMNA (1.00) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL3399 | 0.82 | LMNA (1.00) | LMNACNR1ADRA1ATDP1KDM4E | |
| Ethambutol SCHEMBL9906602 | 0.82 | LMNA (1.00) | LMNACNR1ADRA1ATDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0797442-A4 | TREATMENT OF OPTIC NEURITIS | MASSACHUSETTS EYE & EAR INFIRM (US) | 1998-04-15 | — | — | EP | disclosed |
| EP-0797442-A1 | TREATMENT OF OPTIC NEURITIS | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 1997-10-01 | — | — | EP | disclosed |
| WO-1996000073-A1 | TREATMENT OF OPTIC NEURITIS | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 1996-01-04 | — | — | WO | disclosed |