Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | CHKA | P35790 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18256171 | 0.91 | CHKA (0.42) | MC4RNPSR1CA2SIGMAR1CHKA | |
| SCHEMBL23874621 | 0.88 | CHKA (0.50) | CA2ALDH1A1SIGMAR1CHKATDP1 | |
| SCHEMBL5807354 | 0.88 | HRH3 (0.43) | MC4RNPSR1CA2SIGMAR1CHKA | |
| SCHEMBL19250975 | 0.86 | PAOX (0.38) | MC4RPAOXLMNANPSR1CA2 | |
| SCHEMBL10063749 | 0.84 | POLB (0.41) | MC4RLMNAPHGDHSIGMAR1 | |
| SCHEMBL13923300 | 0.84 | KDM4E (0.48) | ALDH1A1SIGMAR1KDM4EGAAALOX15 | |
| SCHEMBL18772772 | 0.82 | CARM1 (0.48) | ALDH1A1PHGDHMGLLSIGMAR1KDM4E | |
| SCHEMBL24510598 | 0.82 | HRH3 (0.41) | MC4RALDH1A1SIGMAR1TDP1KDM4E | |
| SCHEMBL6143515 | 0.81 | PAOX (0.46) | MC4RPAOXLMNAMGLLSIGMAR1 | |
| SCHEMBL40839 | 0.81 | PAOX (0.46) | MC4RPAOXLMNAMGLLSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210300922-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | FAES FARMA, S.A. (ES) | 2021-09-30 | — | — | US | disclosed |
| US-20210147478-A1 | INHIBITORS OF BLOOD COAGULATION FACTOR XIII | ZEDIRA GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| US-9914719-B2 | Hydroxybenzamide derivatives and their use as inhibitors of HSP90 | ASTEX THERAPEUTICS LTD. (GB) | 2018-03-13 | — | — | US | disclosed |
| US-9730912-B2 | Pharmaceutical compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2017-08-15 | — | — | US | disclosed |
| US-8496716-B2 | Method for producing Mannich adducts that contain polyisobutylene phenol | BASF SE (DE) | 2013-07-30 | — | — | US | disclosed |
| US-8491879-B2 | Ammonium-polyurethane- and/or polycarbonate compounds | MOMENTIVE PERFORMANCE MATERIALS GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-8263598-B2 | Substituted sulfonamide compounds | GRUENENTHAL GMBH (DE) | 2012-09-11 | — | — | US | disclosed |
| US-8178535-B2 | Substituted sulfonamide compounds having bradykinin 1 receptor activity and use thereof as medicaments | GRUENENTHAL GMBH (DE) | 2012-05-15 | — | — | US | disclosed |
| US-20110251114-A1 | METHOD FOR PRODUCING MANNICH ADDUCTS THAT CONTAIN POLYISOBUTYLENE PHENOL | BASF SE (DE) | 2011-10-13 | — | — | US | disclosed |
| US-8016898-B1 | Method for producing Mannich adducts that contain polyisobutylene phenol | BASF AKTIENGESELLSCHAFT (DE) | 2011-09-13 | — | — | US | disclosed |
| US-20090186899-A1 | Substituted Sulfonamide Compounds | GRUENENTHAL GMBH (DE) | 2009-07-23 | — | — | US | disclosed |
| US-20080274924-A1 | Alkylation of a phenol with polyisobutylene at low temperature in presence of alkylation catalyst; then formaldehyde and amine; oil and fuel additive | BASF AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | US | disclosed |
| US-7196101-B2 | Bis(5-aryl-2-pyridyl) compound having excellent immunoglobulin (IgE) antibody production inhibiting activity, useful for the prevention or treatment of allergic immune diseases | KOWA CO., LTD (JP) | 2007-03-27 | — | — | US | disclosed |
| EP-1226188-B1 | METHOD FOR PRODUCING MANNICH ADDUCTS THAT CONTAIN POLYISOBUTYLENE PHENOL | BASF AG (DE) | 2004-12-01 | — | — | EP | disclosed |
| EP-1233990-B1 | METHOD FOR PRODUCING MANNICH ADDUCTS THAT CONTAIN POLYISOBUTYLENE PHENOL | BASF AG (DE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1233990-A1 | METHOD FOR PRODUCING MANNICH ADDUCTS THAT CONTAIN POLYISOBUTYLENE PHENOL | BASF AKTIENGESELLSCHAFT (DE) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001025293-A1 | METHOD FOR PRODUCING MANNICH ADDUCTS THAT CONTAIN POLYISOBUTYLENE PHENOL | BASF AKTIENGESELLSCHAFT (DE) | 2001-04-12 | — | — | WO | disclosed |
| US-3983141-A | Derivatives of 5-hydroxy-6-diloweralkylaminomethyl-benzofurans | GRINEV ALEXEI NIKOLAEVICH | 1976-09-28 | — | — | US | disclosed |
| US-3957761-A | Process for the production of 1-aminomethyl-6-phenyl-4h-s-triazolo-[4,3-a][1]benzodiazepines and intermediates | THE UPJOHN COMPANY (US) | 1976-05-18 | — | — | US | disclosed |
| US-3933816-A | 3-(Substituted aminomethyl)-7-substituted-3,5-dihydro-as-triazino[4,3-a][1,5]benzodiazepines | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251114-A1 | METHOD FOR PRODUCING MANNICH ADDUCTS THAT CONTAIN POLYISOBUTYLENE PHENOL | ADH1C, FANCF, PCNA | MC4R 1082/4885PAOX 299/4885LMNA 906/4885 |
| US-20210300922-A1 | PYRIDOPYRIMIDINES AS HISTAMINE H4-RECEPTOR INHIBITORS | HRH4, HRH3, HRH2 | MC4R 324/4885PAOX 2766/4885LMNA 3761/4885 |
| US-20090186899-A1 | Substituted Sulfonamide Compounds | BDKRB1, BDKRB2, NPSR1 | MC4R 503/4885PAOX 3717/4885LMNA 1162/4885 |
| US-20210147478-A1 | INHIBITORS OF BLOOD COAGULATION FACTOR XIII | TFPI, F11, F13B | MC4R 4575/4885PAOX 2803/4885LMNA 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.