Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.82 |
| ▸ | JAK2 | O60674 | 10/20 | 0.82 |
| ▸ | JAK1 | P23458 | 10/20 | 0.82 |
| ▸ | TYK2 | P29597 | 5/20 | 0.82 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.82 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.82 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.77 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.77 |
| ▸ | STK3 | Q13188 | 3/20 | 0.77 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.77 |
| ▸ | CAMK2D | Q13557 | 3/20 | 0.77 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.77 |
| ▸ | MARK3 | P27448 | 2/20 | 0.77 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.77 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.77 |
| ▸ | ABL1 | P00519 | 2/20 | 0.77 |
| ▸ | LCK | P06239 | 2/20 | 0.77 |
| ▸ | FYN | P06241 | 2/20 | 0.77 |
| ▸ | RET | P07949 | 2/20 | 0.77 |
| ▸ | DMPK | Q09013 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3678056 | 1.00 | JAK3 (0.82) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL7495463 | 0.94 | JAK3 (0.73) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4070029 | 0.93 | JAK3 (0.86) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL24327026 | 0.92 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL22511887 | 0.92 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL13956994 | 0.92 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL28413805 | 0.92 | JAK3 (0.89) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL17279276 | 0.90 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL2320931 | 0.90 | JAK3 (0.85) | JAK3JAK2JAK1TYK2PKN2 | |
| SCHEMBL4061609 | 0.90 | JAK3 (1.00) | JAK3JAK2JAK1TYK2PKN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1609781-B1 | Optical resolution of (1-benzyl-4-methylpiperidin-3-yl)-methylamine | PFIZER PROD INC (US) | 2011-08-10 | — | — | EP | disclosed |
| US-7432370-B2 | Mixing a racemic mixture of enantiomers of pyrrolo[2,3-d]pyrimidine compounds in a solvent, with a resolving compound having a defined stereospecificity, to form a solution and with resolving agent being capable of binding with enantiomers to form a precipitate collecting precipitate and purifying | PFIZER INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7301023-B2 | Chiral salt resolution | PFIZER INC. (US) | 2007-11-27 | — | — | US | disclosed |
| EP-1666481-A2 | OPTICAL RESOLUTION OF (1-BENZYL-4-METHYLPIPERIDIN-3-YL)-METHYLAMINE AND THE USE THEREOF FOR THE PREPARATION OF PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS PROTEIN KINASES INHIBITORS | Pfizer Products Incorporated (US) | 2006-06-07 | — | — | EP | disclosed |
| EP-1609781-A1 | Optical resolution of (1-benzyl-4-methylpiperidin-3-yl)-methylamine | Pfizer Products Incorporated (US) | 2005-12-28 | — | — | EP | disclosed |
| US-20040229923-A1 | Chiral salt resolution | PFIZER INC. | 2004-11-18 | — | — | US | disclosed |
| US-20030073719-A1 | Chiral salt resolution | PFIZER INC. | 2003-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229923-A1 | Chiral salt resolution | REN, SRR, RER1 | JAK3 4250/4885JAK2 3069/4885JAK1 3549/4885 |
| US-20030073719-A1 | Chiral salt resolution | REN, SRR, RER1 | JAK3 4250/4885JAK2 3069/4885JAK1 3549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.