Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | UBE2M | P61081 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23197769 | 0.76 | TP53 (0.49) | LMNARAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL23198944 | 0.73 | TP53 (0.46) | LMNAPOLBRAB9ASMN1; SMN2TP53 | |
| SCHEMBL23197834 | 0.73 | TP53 (0.52) | LMNARAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL23198467 | 0.69 | TP53 (0.42) | LMNARAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL23198655 | 0.68 | EPHX2 (0.42) | LMNAPOLBRAB9AEPHX2SMN1; SMN2 | |
| SCHEMBL23198512 | 0.66 | P2RX1 (0.40) | LMNAPOLBRAB9AEPHX2ALDH1A1 | |
| SCHEMBL19766263 | 0.64 | L3MBTL1 (0.61) | LMNARAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL23197819 | 0.64 | MEN1 (0.33) | MEN1KMT2ATDP1 | |
| SCHEMBL7535310 | 0.62 | TDP1 (0.62) | LMNARAB9ASMN1; SMN2TP53MEN1 | |
| SCHEMBL18665944 | 0.62 | TP53 (0.56) | LMNARAB9ASMN1; SMN2TP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021064077-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES AS IRAK4 INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2021-04-08 | — | — | WO | disclosed |