Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.58 |
| ▸ | HINT1 | P49773 | 5/20 | 0.58 |
| ▸ | NT5E | P21589 | 1/20 | 0.55 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 2/20 | 0.52 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | TGM2 | P21980 | 1/20 | 0.51 |
| ▸ | PNP | P00491 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23200376 | 1.00 | TAAR1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL800400 | 1.00 | TAAR1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL780400 | 1.00 | TAAR1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL23710671 | 1.00 | TAAR1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL800874 | 1.00 | TAAR1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL23710670 | 1.00 | TAAR1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL7535718 | 0.92 | HINT1 (0.58) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL7541561 | 0.89 | TAAR1 (0.56) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL7111072 | 0.89 | HINT1 (0.55) | TAAR1HINT1NT5ESTING1PDE3B | |
| SCHEMBL2424287 | 0.89 | HINT1 (0.55) | TAAR1HINT1NT5ESTING1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220290145-A1 | Modified RNA Agents with Reduced Off-Target Effect | ALNYLAM PHARMACEUTICALS, INC. (US) | 2022-09-15 | — | — | US | disclosed |
| US-20210238595-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | ALNYLAM PHARMACEUTICALS, INC. (US) | 2021-08-05 | — | — | US | disclosed |
| EP-3802827-A1 | MODIFIED RNA AGENTS WITH REDUCED OFF-TARGET EFFECT | Alnylam Pharmaceuticals, Inc. (US) | 2021-04-14 | — | — | EP | disclosed |