SCHEMBL2424287

SCHEMBL2424287

Nc1nc2c(ncn2[C@@H]2O[C@H](C(O)F)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.55

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HINT1 P49773 4/20 0.55
▸ NT5E P21589 1/20 0.55
▸ STING1 Q86WV6 3/20 0.55
▸ PDE3B Q13370 1/20 0.55
▸ PDE3A Q14432 1/20 0.55
▸ TAAR1 Q96RJ0 1/20 0.54
▸ GSK3A P49840 2/20 0.52
▸ RPS6KA3 P51812 2/20 0.52
▸ MAPK14 Q16539 2/20 0.52
▸ PNP P00491 1/20 0.52
▸ TGM2 P21980 1/20 0.51
▸ KRAS P01116 1/20 0.51
▸ HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7535718 0.92 HINT1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL23710670 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL780400 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL800400 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL23200376 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL23200375 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL7111072 0.89 HINT1 (0.55) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL23710671 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL7541561 0.89 TAAR1 (0.56) HINT1NT5ESTING1PDE3BPDE3A
SCHEMBL800874 0.89 TAAR1 (0.58) HINT1NT5ESTING1PDE3BPDE3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 479 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122095093-A RNAi agents for inhibiting expression of inhibin subunit beta E (INHBE), pharmaceutical compositions and methods of use — 2026-05-26 — — CN claimed
EP-4661900-A1 IMMUNE EFFECTOR CELLS STABLY AND TRANSIENTLY EXPRESSING NUCLEIC ACIDS BIONTECH CELL & GENE THERAPIES GMBH (DE) 2025-12-17 — — EP claimed
WO-2025132708-A1 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF HUNTINGTON'S DISEASE PROQR THERAPEUTICS II B.V. (NL) 2025-06-26 — — WO claimed
WO-2025104239-A1 ANTISENSE OLIGONUCLEOTIDES FOR THE TREATMENT OF CLASSIC GALACTOSEMIA PROQR THERAPEUTICS II B.V. (NL) 2025-05-22 — — WO claimed
EP-4555086-A1 OLIGONUCLEOTIDES FOR ADAR-MEDIATED RNA EDITING AND USE THEREOF ProQR Therapeutics II B.V. (NL) 2025-05-21 — — EP claimed
CN-116514908-B EGFR targeting polypeptide and application thereof in preparation of targeting drug delivery system for treating EGFR abnormal expression diseases 四川大学华西医院 2025-05-16 — — CN claimed
CN-119907691-A Carbohydrate-oligonucleotide conjugates, pharmaceutical compositions and therapeutic uses 厦门甘宝利生物医药有限公司 2025-04-29 — — CN claimed
CN-115591086-B Method for manufacturing drug coated balloon and drug coated balloon 北京先瑞达医疗科技有限公司 2025-04-29 — — CN claimed
CN-118512703-B Medicine sacculus pipe 北京海盛医疗器械有限公司 2025-04-08 — — CN claimed
CN-119789859-A Treatment of non-alcoholic fatty liver disease 箭头药业股份有限公司 2025-04-08 — — CN claimed
US-20140147454-A1 TERMINALLY MODIFIED RNA MODERNA THERAPEUTICS, INC. (US) 2014-05-29 — — US claimed
WO-2013167743-A1 USE OF COMPOUNDS FOR THE TREATMENT OF PAIN AKRON MOLECULES GMBH (AT) 2013-11-14 — — WO claimed
US-20130266640-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS MODERNA THERAPEUTICS, INC. 2013-10-10 — — US claimed
US-20130259923-A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF SECRETED PROTEINS modeRNA Therapeutics (US) 2013-10-03 — — US claimed
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS modeRNA Therapeutics (US) 2013-06-20 — — US claimed
EP-1485395-A2 NUCLEOTIDE MIMICS AND THEIR PRODRUGS Biota, Inc. (US) 2004-12-15 — — EP claimed
WO-2003072757-A9 NUCLEOTIDE MIMICS AND THEIR PRODRUGS BIOTA INC (US) 2004-10-21 — — WO claimed
WO-2003072757-A2 NUCLEOTIDE MIMICS AND THEIR PRODRUGS BIOTA, INC. (US) 2003-09-04 — — WO claimed
US-20020177695-A1 Nucleic acid probes and methods DUKE UNIVERSITY 2002-11-28 — — US claimed
US-6288221-B1 REPLACING NUCLEOSIDE WITH DIMETHOXYTRITYL, PHOSPHORAMIDITE, OR HALONUCLEOSIDE DERIVATIVE; ELECTROCHEMICAL OR PHOTOCHEMICAL DETECTION OF NUCLEIC ACID SEQUENCES DUKE UNIVERSITY 2001-09-11 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130156849-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 HINT1 440/4885NT5E 44/4885STING1 149/4885
US-20130266640-A1 MODIFIED NUCLEOSIDE, NUCLEOTIDE, AND NUCLEIC ACID COMPOSITIONS NSUN2, RNMT, NSUN3 HINT1 440/4885NT5E 44/4885STING1 149/4885
US-20140147454-A1 TERMINALLY MODIFIED RNA RNGTT, NSUN3, RNMT HINT1 2512/4885NT5E 234/4885STING1 660/4885
US-20020177695-A1 Nucleic acid probes and methods NUDT1, NT5C3B, NT5C2 HINT1 96/4885NT5E 9/4885STING1 136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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