Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 4/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.49 |
| ▸ | WNT1 | P04628 | 2/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23201605 | 1.00 | USP30 (0.57) | USP30PIM1IRAK4WNT1DYRK1A | |
| SCHEMBL31188609 | 1.00 | USP30 (0.57) | USP30PIM1IRAK4WNT1DYRK1A | |
| SCHEMBL29963673 | 1.00 | USP30 (0.57) | USP30PIM1IRAK4WNT1DYRK1A | |
| SCHEMBL31188553 | 0.91 | IRAK4 (0.53) | USP30PIM1IRAK4WNT1DYRK1A | |
| SCHEMBL357738 | 0.80 | ALDH1A1 (0.61) | HRH2HRH1CHRNB2CHRNA4KDM5A | |
| SCHEMBL10224770 | 0.80 | ALDH1A1 (0.61) | HRH2HRH1CHRNB2CHRNA4KDM5A | |
| SCHEMBL31188493 | 0.80 | HRH2 (0.46) | USP30WNT1DYRK1AHRH2HRH1 | |
| SCHEMBL18918856 | 0.78 | USP30 (0.52) | USP30PIM1CNR2CHRNB2CHRNB4 | |
| SCHEMBL23201599 | 0.78 | PIM1 (0.63) | USP30PIM1IRAK4WNT1DYRK1A | |
| SCHEMBL31162221 | 0.77 | MC2R (0.54) | USP30IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802500-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2021-04-14 | — | — | EP | claimed |