Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | CTSA | P10619 | 3/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | MC2R | Q01718 | 2/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30090944 | 0.84 | MC2R (0.54) | IRAK4NTRK1USP30MC2R | |
| SCHEMBL30090945 | 0.84 | MC2R (0.54) | IRAK4NTRK1USP30MC2R | |
| SCHEMBL31162221 | 0.84 | MC2R (0.54) | IRAK4NTRK1USP30MC2R | |
| SCHEMBL31188553 | 0.77 | IRAK4 (0.53) | IRAK4ALDH1A1USP30 | |
| SCHEMBL31077928 | 0.75 | DGAT2 (0.49) | IRAK4NTRK1ALDH1A1MC2R | |
| SCHEMBL30200058 | 0.74 | GRM5 (0.62) | NTRK1ALDH1A1 | |
| SCHEMBL31077750 | 0.73 | MC2R (0.55) | MC2R | |
| SCHEMBL31077853 | 0.73 | USP30 (0.59) | USP30MC2R | |
| SCHEMBL12753663 | 0.73 | HSD11B1 (0.64) | IRAK4HRH4SCN9AALDH1A1HPGD | |
| SCHEMBL16465114 | 0.72 | IRAK4 (1.00) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3802500-A1 | MELANOCORTIN SUBTYPE-2 RECEPTOR (MC2R) ANTAGONISTS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2021-04-14 | — | — | EP | claimed |