SCHEMBL2320167

SCHEMBL2320167

COc1ccc(-c2ccc([C]=O)o2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 1/20 0.51
NQO2 P16083 2/20 0.49
ALDH1A1 P00352 6/20 0.48
KDM4E B2RXH2 5/20 0.48
MAPT P10636 5/20 0.48
PKM P14618 3/20 0.48
HPGD P15428 4/20 0.44
CYP3A4 P08684 4/20 0.44
HSD17B10 Q99714 3/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
MAOB P27338 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
NPC1 O15118 2/20 0.43
LMNA P02545 2/20 0.43
TP53 P04637 2/20 0.43
THRB P10828 2/20 0.43
RAB9A P51151 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11777406 0.82 NQO2 (0.49) EGFRNQO2ALDH1A1KDM4EMAPT
SCHEMBL6010284 0.80 SLC9A1 (0.52) ALDH1A1KDM4EMAPTHPGDCYP3A4
SCHEMBL2318469 0.79 ALDH1A1 (0.44) NQO2ALDH1A1KDM4EMAPTPKM
SCHEMBL2322085 0.76 ALDH1A1 (0.44) ALDH1A1KDM4EMAPTPKMHPGD
SCHEMBL2325827 0.76 KDM4E (0.52) NQO2ALDH1A1KDM4EMAPTPKM
SCHEMBL2324987 0.75 TNKS (0.42) ALDH1A1KDM4EMAPTHPGDHSD17B10
SCHEMBL2359506 0.75 HDAC6 (0.42) MAPTNPC1LMNATP53THRB
SCHEMBL2346044 0.75 ALDH1A1 (0.46) NQO2ALDH1A1MAPTPKMHPGD
SCHEMBL13680560 0.73 GSK3B (0.59) EGFRNQO2ALDH1A1KDM4EMAPT
SCHEMBL28568726 0.73 NPC1 (0.61) EGFRNQO2ALDH1A1KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011094890-A1 PHENYLALANINE DERIVATIVES AND THEIR USE AS NON-PEPTIDE GLP-1 RECEPTOR MODULATORS ARGUSINA INC. (US) 2011-08-11 WO disclosed
EP-1697335-A1 FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2006-09-06 EP disclosed
WO-2005063727-A1 FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2005-07-14 WO disclosed