Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 2/20 | 0.35 |
| ▸ | HEXA | P06865 | 1/20 | 0.34 |
| ▸ | HEXB | P07686 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24803365 | 0.81 | KDM4E (0.39) | ALDH1A1ADRA1AHRH1ADRA1BKDM4E | |
| SCHEMBL5088814 | 0.79 | ADRA1A (0.43) | ALDH1A1ADRA1AHRH1ADRA1BKDM4E | |
| SCHEMBL24077344 | 0.79 | ADRA1A (0.37) | ALDH1A1ADRA1AHRH1ADRA1BKDM4E | |
| SCHEMBL24246976 | 0.78 | ADRA1A (0.36) | ALDH1A1ADRA1AHRH1ADRA1BKDM4E | |
| SCHEMBL13896321 | 0.77 | MEN1 (0.37) | ALDH1A1KDM4EPTGS2LMNACYP1A2 | |
| SCHEMBL24667412 | 0.77 | HRH3 (0.35) | ALDH1A1KDM4EPTGS2LMNACYP1A2 | |
| SCHEMBL31366245 | 0.76 | MPO (0.40) | ALDH1A1KDM4EPTGS2LMNACYP1A2 | |
| SCHEMBL17723466 | 0.76 | PTGS2 (0.36) | ALDH1A1KDM4EPTGS2LMNACYP1A2 | |
| SCHEMBL11157346 | 0.74 | KDM4E (0.55) | KDM4EUSP2MAPK1CYP1A2POLB | |
| SCHEMBL24802523 | 0.73 | NPSR1 (0.48) | ALDH1A1KDM4EUSP2MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4685140-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2026-01-28 | — | — | EP | disclosed |
| EP-3801528-B1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2025-08-06 | — | — | EP | disclosed |
| US-12286420-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2025-04-29 | — | — | US | disclosed |
| CN-112533601-B | EAAT2 activators and methods of use thereof | 俄亥俄州创新基金会 | 2024-08-16 | — | — | CN | disclosed |
| US-20240208936-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION (US) | 2024-06-27 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-11702403-B2 | EAAT2 activators and methods of using thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2023-07-18 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2022268209-A1 | DERIVATIVE HAVING PYRIMIDINE-FUSED CYCLIC STRUCTURE, AND USE THEREOF | 四川汇宇制药股份有限公司 | 2022-12-29 | — | — | WO | disclosed |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | OHIO STATE INNOVATION FOUNDATION | 2021-06-10 | — | — | US | disclosed |
| EP-3801528-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | Ohio State Innovation Foundation (US) | 2021-04-14 | — | — | EP | disclosed |
| CN-112533601-A | EAAT2 activators and methods of use thereof | 俄亥俄州创新基金会 | 2021-03-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702403-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | ALDH1A1 1079/4885ADRA1A 1244/4885HRH1 2550/4885 |
| US-12286420-B2 | EAAT2 activators and methods of using thereof | SLC1A2, SLC1A1, SLC18A2 | ALDH1A1 1079/4885ADRA1A 1244/4885HRH1 2550/4885 |
| US-20230138663-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | ALDH1A1 1079/4885ADRA1A 1244/4885HRH1 2550/4885 |
| US-20240208936-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | ALDH1A1 1079/4885ADRA1A 1244/4885HRH1 2550/4885 |
| US-20210171497-A1 | EAAT2 ACTIVATORS AND METHODS OF USING THEREOF | SLC1A2, SLC1A1, SLC18A2 | ALDH1A1 1079/4885ADRA1A 1244/4885HRH1 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.