Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.69 |
| ▸ | DRD3 | P35462 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.69 |
| ▸ | HTR7 | P34969 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | GLA | P06280 | 1/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30080702 | 1.00 | DRD2 (0.69) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| SCHEMBL8562790 | 1.00 | DRD2 (0.69) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| SCHEMBL2320320 | 1.00 | DRD2 (0.69) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL8565266 | 0.98 | DRD2 (0.66) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| SCHEMBL14761789 | 0.85 | DRD2 (0.75) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| SCHEMBL7668612 | 0.84 | DRD2 (0.86) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| Nan-190 SCHEMBL30080779 | 0.81 | HTR1A (1.00) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| Nan-190 SCHEMBL29389115 | 0.81 | HTR1A (1.00) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| Nan-190 SCHEMBL2231820 | 0.81 | HTR1A (1.00) | DRD2DRD3ALDH1A1ADRA1DADRA1A | |
| SCHEMBL10835973 | 0.81 | DRD2 (1.00) | DRD2DRD3ALDH1A1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0494604-B1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-10-07 | — | — | EP | claimed |
| EP-0494604-A1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-15 | — | — | EP | claimed |
| US-5130315-A | Treatment of psychosis | Wittekind, Raymond R. (US) | 1992-07-14 | — | — | US | claimed |
| CN-108329282-B | Phenylpiperazine derivative and preparation method and application thereof | 新乡医学院 | 2022-01-07 | — | — | CN | disclosed |
| EP-2354136-B1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | INST PHARM & TOXICOLOGY AMMS (CN) | 2016-02-24 | — | — | EP | disclosed |
| US-9227944-B2 | Dopamine D3 receptor ligands and preparation and medical uses of the same | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY SCIENCE P.L.A. CHINA (CN) | 2016-01-05 | — | — | US | disclosed |
| US-20140329831-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCE P.L.A. CHINA (CN) | 2014-11-06 | — | — | US | disclosed |
| US-8829001-B2 | Dopamine D3 receptor ligands and preparation and medical uses of the same | The Institute of Pharmacology and Toxicology Academy of Military Medical Science P.L.A. China (CN) | 2014-09-09 | — | — | US | disclosed |
| US-20110319423-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | Institute of Pharmacology and Toxicology Academy of Military Medical Science, P.L.A (CN) | 2011-12-29 | — | — | US | disclosed |
| EP-2354136-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS, THE PREPARATION AND USE THEREOF | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China (CN) | 2011-08-10 | — | — | EP | disclosed |
| EP-0494604-B1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-10-07 | — | — | EP | disclosed |
| EP-0494604-A1 | 1-Piperazinyl-2-butenes and 2-butynes, intermediates thereof, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-07-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319423-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | DRD3, DRD2, SLC6A3 | DRD2 2/4885DRD3 1/4885ALDH1A1 1118/4885 |
| US-20140329831-A1 | NOVEL DOPAMINE D3 RECEPTOR LIGANDS AND PREPARATION AND MEDICAL USES OF THE SAME | DRD3, DRD2, SLC6A3 | DRD2 2/4885DRD3 1/4885ALDH1A1 1118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.