SCHEMBL23204459

SCHEMBL23204459

c1cnc2[nH]cc(-c3csc(-c4cocn4)n3)c2c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 5/20 0.53
CCNB1 P14635 5/20 0.53
GSK3B P49841 4/20 0.53
ROCK1 Q13464 6/20 0.47
CDK9 P50750 7/20 0.47
CCNT1 O60563 5/20 0.47
CCNA2 P20248 5/20 0.47
CDK2 P24941 5/20 0.47
CDK5 Q00535 3/20 0.47
PDPK1 O15530 1/20 0.47
CCNA1 P78396 1/20 0.47
CDK5R1 Q15078 1/20 0.47
DYRK1A Q13627 3/20 0.45
MEN1 O00255 1/20 0.44
MAPT P10636 1/20 0.44
RAB9A P51151 1/20 0.44
KMT2A Q03164 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
GLS O94925 1/20 0.44
GLS2 Q9UI32 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23163137 0.81 CDK1 (0.57) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL17243071 0.80 RAB9A (0.61) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL23163224 0.80 CDK1 (0.52) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL23163214 0.78 CDK1 (0.52) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL23163147 0.78 CDK9 (0.57) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL4474062 0.77 PDPK1 (0.63) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL23204441 0.76 CDK1 (0.53) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL24440732 0.76 KMT2A (0.54) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL23163176 0.76 CDK1 (0.60) CDK1CCNB1GSK3BROCK1CDK9
SCHEMBL23163138 0.75 CDK1 (0.52) CDK1CCNB1GSK3BROCK1CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021064141-A1 INHIBITORS OF DUAL SPECIFICITY TYROSINE PHOSPHORYLATION REGULATED KINASE 1B TOLREMO THERAPEUTICS AG (CH) 2021-04-08 WO disclosed