Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.59 |
| ▸ | CDK1 | P06493 | 4/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 5/20 | 0.55 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.53 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24440732 | 0.91 | KMT2A (0.54) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL23163185 | 0.86 | GSK3B (0.49) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL24440421 | 0.83 | RAB9A (0.52) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL23163137 | 0.82 | CDK1 (0.57) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL23163147 | 0.82 | CDK9 (0.57) | ROCK1CDK1CCNB1GSK3BCDC7 | |
| SCHEMBL98272 | 0.82 | ROCK1 (0.62) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL4474062 | 0.81 | PDPK1 (0.63) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL17243087 | 0.81 | MEN1 (0.84) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL23204441 | 0.80 | CDK1 (0.53) | RAB9ASMN1; SMN2KMT2AMEN1MAPT | |
| SCHEMBL23204459 | 0.80 | CDK1 (0.53) | RAB9ASMN1; SMN2KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104348-A1 | SMALL MOLECULE INHIBITORS OF NF-KB INDUCING KINASE | JANSSEN PHARMACEUTICA NV (BE) | 2022-05-19 | — | — | WO | disclosed |
| US-11123340-B2 | Small-molecule UT-A-selective urea transport inhibitors | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200016147-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-01-16 | — | — | US | disclosed |
| US-20170239235-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INIHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-08-24 | — | — | US | disclosed |
| WO-2015172065-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170239235-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INIHIBITORS | SLC14A1, UTS2R, SLC28A1 | RAB9A 1511/4885SMN1; SMN2 4696/4885KMT2A 2381/4885 |
| US-11123340-B2 | Small-molecule UT-A-selective urea transport inhibitors | SLC14A1, UTS2R, SLC75A1 | RAB9A 1609/4885SMN1; SMN2 4768/4885KMT2A 1864/4885 |
| US-20200016147-A1 | SMALL-MOLECULE UT-A-SELECTIVE UREA TRANSPORT INHIBITORS | SLC14A1, UTS2R, SLC75A1 | RAB9A 1609/4885SMN1; SMN2 4768/4885KMT2A 1864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.