Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ELOVL1 | Q9BW60 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14812729 | 0.86 | KMT2A (0.44) | KMT2AMEN1ESR1CYP2C9FAAH | |
| SCHEMBL23166003 | 0.83 | KDM4E (0.46) | KMT2AHDAC1HDAC6MEN1CYP2C9 | |
| SCHEMBL24196386 | 0.83 | MALT1 (0.37) | KMT2AHDAC1HDAC6SCN9ACYP2C9 | |
| SCHEMBL24196207 | 0.83 | HDAC1 (0.39) | HDAC1HDAC6KAT6A | |
| SCHEMBL30104774 | 0.83 | KDM4E (0.46) | KMT2AHDAC1HDAC6MEN1CYP2C9 | |
| SCHEMBL15754746 | 0.82 | KMO (0.45) | KMT2AMEN1ATM | |
| SCHEMBL31587364 | 0.79 | KMT2A (0.46) | KMT2AMEN1ALDH1A1ATM | |
| SCHEMBL14150735 | 0.78 | KMT2A (0.64) | KMT2AMEN1CYP2C9ATM | |
| SCHEMBL15755051 | 0.76 | KEAP1 (0.47) | KMT2AMEN1KEAP1SCN9AELOVL1 | |
| SCHEMBL23165941 | 0.76 | CYP3A4 (0.39) | CYP2C9ALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022011274-A1 | SUBSTITUTED 1,6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2022-01-13 | — | — | WO | disclosed |
| WO-2021067569-A1 | SUBSTITUTED 1, 6-NAPHTHYRIDINE INHIBITORS OF CDK5 | GOLDFINCH BIO, INC. (US) | 2021-04-08 | — | — | WO | disclosed |