Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAN2A1 | Q16706 | 1/20 | 0.32 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.32 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2320767 | 1.00 | SMN1; SMN2 (0.46) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL15957077 | 0.77 | SMN1; SMN2 (0.65) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL2321113 | 0.75 | CYP26A1 (0.43) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL10526965 | 0.74 | RIPK1 (0.49) | KDM4EL3MBTL1RIPK1MAN2A1MAN1B1 | |
| SCHEMBL31146140 | 0.73 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL7206110 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL7172042 | 0.71 | SMN1; SMN2 (0.51) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL13458399 | 0.69 | SLC18A3 (0.39) | SMN1; SMN2CYP2C19ALDH1A1ALOX15IDO1 | |
| SCHEMBL11677763 | 0.68 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP2C19ALDH1A1KDM4EMAPT | |
| SCHEMBL1134347 | 0.68 | IDO1 (0.47) | CYP2C19ALDH1A1ALOX15IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| EP-2356105-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. Organon (NL) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010052198-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. ORGANON (NL) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052198-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. ORGANON (NL) | 2010-05-14 | — | — | WO | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | CNR1, CNR2, TRPV1 | SMN1; SMN2 1710/4885CYP2C19 772/4885ALDH1A1 1934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.