Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | MMP7 | P09237 | 3/20 | 0.34 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2331441 | 0.80 | MAPT (0.45) | HTTCYP2C19SMN1; SMN2CYP2C9ALDH1A1 | |
| SCHEMBL2331444 | 0.80 | MAPT (0.45) | HTTCYP2C19SMN1; SMN2CYP2C9ALDH1A1 | |
| SCHEMBL2899494 | 0.79 | CYP2C19 (0.56) | HTTCYP2C19SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31146140 | 0.76 | SMN1; SMN2 (0.41) | CYP26A1HTTCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL2359345 | 0.76 | CYP26A1 (0.46) | CYP26A1HTTCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL2320758 | 0.75 | SMN1; SMN2 (0.46) | CYP26A1CYP2C19SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL2320767 | 0.75 | SMN1; SMN2 (0.46) | CYP26A1CYP2C19SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL18425130 | 0.74 | ALDH1A1 (0.43) | CYP26A1HTTCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL16972136 | 0.74 | ALDH1A1 (0.43) | CYP26A1HTTCYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL614703 | 0.73 | MMP1 (0.38) | MMP3MMP7MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2356105-B1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | MSD OSS BV (NL) | 2013-04-10 | — | — | EP | disclosed |
| US-8188123-B2 | (Pyrrolidin-2-yl)phenyl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2012-05-29 | — | — | US | disclosed |
| EP-2356105-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. Organon (NL) | 2011-08-17 | — | — | EP | disclosed |
| WO-2010052198-A1 | ( PYRROLIDIN-2 -YL) PHENYL DERIVATIVES FOR USE IN THE TREATMENT OF PAIN | N.V. ORGANON (NL) | 2010-05-14 | — | — | WO | disclosed |
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | N.V. ORGANON | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113493-A1 | (PYRROLIDIN-2-YL)PHENYL DERIVATIVES | CNR1, CNR2, TRPV1 | CYP26A1 2454/4885HTT 123/4885CYP2C19 772/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.