Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 4/20 | 0.61 |
| ▸ | WNT3A | P56704 | 3/20 | 0.61 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2379710 | 0.80 | CTNNB1 (0.66) | CTNNB1WNT3ASMYD3MRGPRX4ATM | |
| SCHEMBL2358889 | 0.80 | CTNNB1 (0.66) | CTNNB1WNT3ASMYD3MRGPRX4HDAC4 | |
| SCHEMBL18641649 | 0.77 | CTNNB1 (0.67) | CTNNB1WNT3ASMYD3MRGPRX4HDAC4 | |
| SCHEMBL10407674 | 0.77 | CTNNB1 (0.61) | CTNNB1WNT3ASMYD3MRGPRX4HDAC4 | |
| SCHEMBL15979981 | 0.76 | CTNNB1 (0.78) | CTNNB1WNT3ASMYD3 | |
| SCHEMBL15969201 | 0.76 | CTNNB1 (1.00) | CTNNB1WNT3ASMYD3MRGPRX4 | |
| SCHEMBL3866171 | 0.75 | CTNNB1 (0.59) | CTNNB1WNT3ASMYD3MRGPRX4HDAC4 | |
| SCHEMBL351400 | 0.75 | CTNNB1 (0.64) | CTNNB1WNT3ASMYD3MRGPRX4HDAC4 | |
| SCHEMBL6440716 | 0.75 | ATM (0.64) | CTNNB1WNT3AATMHPGD | |
| SCHEMBL170340 | 0.75 | CTNNB1 (0.59) | CTNNB1WNT3AATMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929712-B | Thienopyrimidinones as TRPA1 inhibitors | 勃林格殷格翰国际有限公司 | 2024-07-23 | — | — | CN | disclosed |
| EP-4045509-A1 | THIENOPYRIMIDONES AS TRPA1 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2022-08-24 | — | — | EP | disclosed |
| CN-114929712-A | Thienopyrimidinones as TRPA1 inhibitors | 勃林格殷格翰国际有限公司 | 2022-08-19 | — | — | CN | disclosed |
| US-11136336-B2 | Thienopyrimidones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-05 | — | — | US | disclosed |
| US-11136336-B2 | Thienopyrimidones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-10-05 | — | — | US | disclosed |
| WO-2021074196-A1 | THIENOPYRIMIDONES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-04-22 | — | — | WO | disclosed |
| WO-2021074196-A1 | THIENOPYRIMIDONES AS TRPA1 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-04-22 | — | — | WO | disclosed |
| US-20210107918-A1 | Novel Thienopyrimidones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-04-15 | — | — | US | disclosed |
| US-20210107918-A1 | Novel Thienopyrimidones | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210107918-A1 | Novel Thienopyrimidones | TRPA1, TRPV1, TRPV2 | CTNNB1 2844/4885WNT3A 4294/4885SMYD3 4815/4885 |
| US-11136336-B2 | Thienopyrimidones | TRPA1, TRPV1, TRPV2 | CTNNB1 2735/4885WNT3A 4313/4885SMYD3 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.