Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.34 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 8/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23209302 | 0.99 | JAK1 (0.34) | ROCK2ROCK1CDC42BPACDC42BPBCDC7 | |
| SCHEMBL23209445 | 0.88 | CDK4 (0.40) | JAK1JAK2CDK4CCND3CCNK | |
| SCHEMBL23209274 | 0.88 | ROCK2 (0.33) | ROCK2ROCK1CDC42BPACDC42BPBMAT2A | |
| SCHEMBL23209563 | 0.87 | JAK1 (0.36) | JAK1JAK2HTR1ACCNKCDK12 | |
| SCHEMBL23209299 | 0.85 | JAK2 (0.45) | JAK1JAK2CDK4CCND1CCND3 | |
| SCHEMBL23209198 | 0.84 | JAK2 (0.45) | JAK1JAK2CDK4CCND1CCND3 | |
| SCHEMBL23209306 | 0.83 | JAK1 (0.34) | ROCK2JAK1JAK2CDK4CCND3 | |
| SCHEMBL23209353 | 0.83 | ROCK2 (0.33) | ROCK2JAK1JAK2CCNKCDK12 | |
| SCHEMBL23209335 | 0.83 | WNT1 (0.35) | JAK1JAK2CDK4CCND3CCNK | |
| SCHEMBL23209263 | 0.81 | JAK1 (0.31) | JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210107901-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | INCYTE CORPORATION | 2021-04-15 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210107901-A1 | BICYCLIC AMINES AS CDK2 INHIBITORS | CDK2, CDK1, CCNI | ROCK2 724/4885ROCK1 1466/4885CDC42BPA 165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.