Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 10/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 8/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29548144 | 0.89 | MAPT (0.44) | MAPTPRMT5WDR77ITKPARP14 | |
| SCHEMBL30498737 | 0.84 | PDK2 (0.39) | CRBNROCK2CYP3A4EPHX2 | |
| SCHEMBL29020381 | 0.84 | PDK2 (0.39) | CRBNROCK2CYP3A4EPHX2 | |
| SCHEMBL22855472 | 0.80 | PRMT5 (0.47) | MAPTPRMT5WDR77ITKPARP14 | |
| SCHEMBL28502079 | 0.77 | MAPT (0.45) | MAPTPRMT5WDR77ITKPARP14 | |
| SCHEMBL22855681 | 0.76 | PRMT5 (0.44) | MAPTPRMT5WDR77ITKPARP14 | |
| SCHEMBL28905226 | 0.74 | MAPT (0.43) | MAPTPRMT5WDR77ITKPARP14 | |
| SCHEMBL28502959 | 0.70 | PRMT5 (0.38) | MAPTPRMT5WDR77CRBNROCK2 | |
| SCHEMBL10269535 | 0.69 | ALDH1A1 (0.63) | MAPTCRBN | |
| SCHEMBL10269075 | 0.68 | POLB (0.55) | ITKCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021068953-A1 | SUBSTITUTED TRICYCLIC COMPOUND AS PRMT5 INHIBITOR AND USE THEREOF | 南京圣和药业股份有限公司 | 2021-04-15 | — | — | WO | disclosed |