Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 10/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22855472 | 0.96 | PRMT5 (0.47) | PRMT5WDR77MAPTPARP14CYP11B1 | |
| SCHEMBL22855214 | 0.87 | GFER (0.38) | PRMT5WDR77JAK1ROCK2CYP3A4 | |
| SCHEMBL28502959 | 0.86 | PRMT5 (0.38) | PRMT5WDR77MAPTCRBNROCK2 | |
| SCHEMBL22855639 | 0.86 | ALDH1A1 (0.46) | MAPTHTTROCK2 | |
| SCHEMBL22855632 | 0.82 | ALDH1A1 (0.53) | MAPTPIM1PIM2JAK1CRBN | |
| SCHEMBL22855475 | 0.82 | ALDH1A1 (0.45) | MAPTROCK2 | |
| SCHEMBL22855213 | 0.81 | CDC7 (0.33) | PRMT5WDR77PIM1PIM2KCNH2 | |
| SCHEMBL23240775 | 0.78 | PRMT5 (0.53) | PRMT5WDR77MAPTJAK1KCNH2 | |
| SCHEMBL28905226 | 0.77 | MAPT (0.43) | PRMT5WDR77MAPTPARP14CYP11B1 | |
| SCHEMBL23212394 | 0.76 | MAPT (0.46) | PRMT5WDR77MAPTPARP14CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020259478-A1 | TRICYCLIC COMPOUND AS PRMT5 INHIBITOR AND APPLICATION THEREOF | 南京圣和药物研发有限公司 | 2020-12-30 | — | — | WO | disclosed |