Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 5/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22855472 | 0.90 | PRMT5 (0.47) | PRMT5WDR77CYP3A4ROCK2CRBN | |
| SCHEMBL22855681 | 0.86 | PRMT5 (0.44) | PRMT5WDR77CYP3A4ROCK2CRBN | |
| SCHEMBL22855214 | 0.85 | GFER (0.38) | PRMT5WDR77JAK3CYP3A4ROCK2 | |
| SCHEMBL22855632 | 0.85 | ALDH1A1 (0.53) | DDB1CRBNMAPT | |
| SCHEMBL22855213 | 0.80 | CDC7 (0.33) | PRMT5WDR77JAK3CYP3A4FGFR1 | |
| SCHEMBL22855475 | 0.76 | ALDH1A1 (0.45) | ROCK2MAPT | |
| SCHEMBL23240775 | 0.72 | PRMT5 (0.53) | PRMT5WDR77MAPT | |
| SCHEMBL22855639 | 0.72 | ALDH1A1 (0.46) | ROCK2MAPT | |
| SCHEMBL22855638 | 0.72 | KDM4E (0.35) | MAPT | |
| SCHEMBL22855637 | 0.71 | CASP3 (0.55) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112125886-A | Tricyclic compound serving as PRMT5 inhibitor and application thereof | 南京圣和药物研发有限公司 | 2020-12-25 | — | — | CN | disclosed |