Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.39 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | PPIA | P62937 | 1/20 | 0.38 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29619704 | 0.97 | SLC6A9 (0.45) | SLC6A9SLC6A5MRGPRX4LRRK2PTGER1 | |
| SCHEMBL23210176 | 0.97 | SLC6A9 (0.45) | SLC6A9SLC6A5MRGPRX4LRRK2PTGER1 | |
| SCHEMBL23209843 | 0.86 | SLC6A9 (0.42) | SLC6A9SLC6A5MRGPRX4PTGER1LIPE | |
| SCHEMBL29619701 | 0.86 | SLC6A9 (0.42) | SLC6A9SLC6A5MRGPRX4PTGER1LIPE | |
| SCHEMBL23212914 | 0.86 | SGMS2 (0.46) | LIPEL3MBTL1LMNAMAPTCFD | |
| SCHEMBL29619700 | 0.83 | SGMS2 (0.48) | LIPEL3MBTL1LMNAMAPTMAPK1 | |
| SCHEMBL23210255 | 0.83 | SGMS2 (0.48) | LIPEL3MBTL1LMNAMAPTMAPK1 | |
| SCHEMBL29619690 | 0.82 | MRGPRX4 (0.41) | MRGPRX4PTGER1LIPEL3MBTL1LMNA | |
| SCHEMBL23295193 | 0.82 | MRGPRX4 (0.41) | MRGPRX4PTGER1LIPEL3MBTL1LMNA | |
| SCHEMBL31357719 | 0.81 | SLC6A9 (0.43) | SLC6A9SLC6A5MRGPRX4LRRK2PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4041389-A1 | 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | Novartis AG (CH) | 2022-08-17 | — | — | EP | disclosed |
| EP-4041737-A1 | 5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | Novartis AG (CH) | 2022-08-17 | — | — | EP | disclosed |
| WO-2021070091-A1 | 5-OXA-2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS AG (CH) | 2021-04-15 | — | — | WO | disclosed |
| WO-2021070090-A1 | 2-AZASPIRO[3.4]OCTANE DERIVATIVES AS M4 AGONISTS | NOVARTIS AG (CH) | 2021-04-15 | — | — | WO | disclosed |