Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 4/20 | 0.49 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | F13A1 | P00488 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.43 |
| ▸ | TGM1 | P22735 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217375 | 0.92 | NAMPT (0.47) | PTPN11NAMPTCA1CA2CA7 | |
| SCHEMBL23217109 | 0.91 | NAMPT (0.47) | PTPN11NAMPTCA1CA2CA7 | |
| SCHEMBL23217131 | 0.89 | PTPN11 (0.55) | PTPN11NAMPTCA1CA2CA7 | |
| SCHEMBL23217265 | 0.86 | PTPN11 (0.56) | PTPN11NAMPTCA1CA2CA7 | |
| SCHEMBL23217370 | 0.85 | CA1 (0.47) | NAMPTCA1CA2CA7PTGDR | |
| SCHEMBL23217303 | 0.85 | NAMPT (0.44) | NAMPTCA1CA2CA7PTGDR | |
| Formic Acid SCHEMBL23217369 | 0.84 | PTPN11 (0.54) | PTPN11NAMPTCA1CA2CA7 | |
| SCHEMBL25381894 | 0.81 | MAPT (0.66) | EPHX2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL30563199 | 0.81 | MAPT (0.66) | EPHX2ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL23217419 | 0.81 | LMNA (0.49) | PTPN11NAMPTCA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124400-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2024-04-18 | — | — | US | disclosed |
| WO-2021072369-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124400-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | CFH, LPAR3, CBR3 | PTPN11 3165/4885NAMPT 1265/4885CA1 1483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.