Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 6/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | F13A1 | P00488 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | TGM1 | P22735 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23217124 | 0.85 | PTPN11 (0.49) | CA1CA2CA7NAMPTEPHX2 | |
| SCHEMBL23217375 | 0.84 | NAMPT (0.47) | CA1CA2CA7NAMPTEPHX2 | |
| SCHEMBL23217373 | 0.84 | EPHX2 (0.47) | CA1CA2CA7NAMPTEPHX2 | |
| SCHEMBL23217109 | 0.83 | NAMPT (0.47) | CA1CA2CA7NAMPTEPHX2 | |
| SCHEMBL23217303 | 0.79 | NAMPT (0.44) | CA1CA2CA7NAMPTEPHX2 | |
| SCHEMBL25381894 | 0.78 | MAPT (0.66) | EPHX2MAPTKDM4EALDH1A1ATM | |
| SCHEMBL30563199 | 0.78 | MAPT (0.66) | EPHX2MAPTKDM4EALDH1A1ATM | |
| SCHEMBL25380430 | 0.76 | TRPV4 (0.55) | PTGDRMAPTALDH1A1TRPV4 | |
| SCHEMBL31252083 | 0.75 | TRPV4 (0.58) | MAPTKDM4EALDH1A1F13A1TGM2 | |
| SCHEMBL23217265 | 0.75 | PTPN11 (0.56) | CA1CA2CA7NAMPTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021072369-A1 | LPXH TARGETING COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF MAKING AND USING THE SAME | DUKE UNIVERSITY (US) | 2021-04-15 | — | — | WO | disclosed |