Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TET3 | O43151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.46 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.46 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554737 | 0.84 | HSD11B1 (0.58) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL2097060 | 0.84 | HSD11B1 (0.58) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL75310 | 0.84 | TET3 (0.61) | HSD11B1HDAC4TET3KMT2AFBXL19 | |
| SCHEMBL3406369 | 0.83 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1975025 | 0.83 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL12020371 | 0.83 | HSD11B1 (0.56) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5007609 | 0.79 | HSD11B1 (0.53) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL4445340 | 0.79 | HSD11B1 (0.53) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL1335906 | 0.79 | ESR2 (0.48) | HSD11B1HDAC4LMNAALDH1A1KMT2A | |
| SCHEMBL1099903 | 0.78 | HDAC4 (0.62) | HSD11B1HDAC4LMNAL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103781763-A | Amine derivatives as potassium channel blockers | BIONOMICS LTD | 2014-05-07 | — | — | CN | disclosed |
| CN-101786948-B | Method for preparing 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone | JIANGSU AGROCHEM LAB CO LTD | 2013-01-30 | — | — | CN | disclosed |
| EP-2357179-A1 | Thiazol-2-yl organic compounds | Novartis AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| CN-102131776-A | Substituted 7-sulfanylmethyl, 7-sulfinylmethyl and 7-sulfonylmethyl indoles and use thereof | BAYER SCHERING PHARMA AG | 2011-07-20 | — | — | CN | disclosed |
| CN-101786948-A | Method for preparing 1-(4-chlorphenyl)-2-cyclopropyl-1-acetone | JIANGSU AGROCHEM LAB | 2010-07-28 | — | — | CN | disclosed |
| US-7754746-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-07-13 | — | — | US | disclosed |
| CN-101374823-A | Organic compounds | NOVARTIS AG (CH) | 2009-02-25 | — | — | CN | disclosed |
| US-20080319033-A1 | 3-{3-[5-(4-acetylphenyl)-4-methylthiazol-2-yl]-ureido}-N-tert-butylpropionamide, exhibiting phosphatidylinositol 3-kinase inhibitory activity and used for treating respiratory system disorders, such as asthma | NOVARTIS AG | 2008-12-25 | — | — | US | disclosed |
| EP-1966175-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068473-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2007-06-21 | — | — | WO | disclosed |
| CN-1215030-C | 1,4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents | AMERICAN CYANAMID CO (US) | 2005-08-17 | — | — | CN | disclosed |
| CN-1167105-A | 1,4-diaryl-2-fluoro-2-butene insecticidal and acaricidal agents | AMERICAN CYANAMID CO (US) | 1997-12-10 | — | — | CN | disclosed |
| CN-1029123-C | Process for preparation of insecticidal cyclopropyl-substituted di(aryl) compounds | FMC CORP (US) | 1995-06-28 | — | — | CN | disclosed |
| CN-1069962-A | The preparation method of parasiticidal cyclopropyl-replacement two (aromatic base) compound | FMC CORP (US) | 1993-03-17 | — | — | CN | disclosed |
| CN-1020091-C | Cyclopropyl-substituted di (aryl) insecticidal compositions | FMC CORP (US) | 1993-03-17 | — | — | CN | disclosed |
| CN-88101892-A | insecticidal cyclopropyl-substituted di (aryl) compounds | — | 1988-11-02 | — | — | CN | disclosed |
| US-4434182-A | Insecticidal substituted-biphenylmethyl oxime ethers | FMC CORPORATION (US) | 1984-02-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319033-A1 | 3-{3-[5-(4-acetylphenyl)-4-methylthiazol-2-yl]-ureido}-N-tert-butylpropionamide, exhibiting phosphatidylinositol 3-kinase inhibitory activity and used for treating respiratory system disorders, such as asthma | AKT3, PIK3R3, PIK3CD | HSD11B1 2776/4885HDAC4 960/4885LMNA 1667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.